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Keywords = remisporine

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18 pages, 484 KiB  
Article
Rare Chromones from a Fungal Mutant of the Marine-Derived Penicillium purpurogenum G59
by Ming-Wen Xia, Cheng-Bin Cui, Chang-Wei Li, Chang-Jing Wu, Ji-Xing Peng and De-Hai Li
Mar. Drugs 2015, 13(8), 5219-5236; https://doi.org/10.3390/md13085219 - 18 Aug 2015
Cited by 35 | Viewed by 5895
Abstract
Three new and rare chromones, named epiremisporine B (2), epiremisporine B1 (3) and isoconiochaetone C (4), along with three known remisporine B (1), coniochaetone A (5) and methyl 8-hydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylate (6 [...] Read more.
Three new and rare chromones, named epiremisporine B (2), epiremisporine B1 (3) and isoconiochaetone C (4), along with three known remisporine B (1), coniochaetone A (5) and methyl 8-hydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylate (6) were isolated from a mutant from the diethyl sulfate (DES) mutagenesis of a marine-derived Penicillium purpurogenum G59. The structures of 24 including the absolute configurations were determined by spectroscopic methods, especially by NMR analysis and electronic circular dichroism (ECD) experiments in conjunction with calculations. The absolute configuration of the known remisporine B (1) was determined for the first time. Compounds 2 and 3 have a rare feature that has only been reported in one example so far. The compounds 16 were evaluated for their cytotoxicity against several human cancer cell lines. The present work explored the great potential of our previous DES mutagenesis strategy for activating silent fungal pathways, which has accelerated the discovery of new bioactive compounds. Full article
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