Previously, various steroidal glycosides were reported from plants of
Cestrum species. However, phytochemical investigation has not been conducted on
Cestrum newellii. A systematic phytochemical investigation of the leaves of
C. newellii resulted in the isolation of eight novel steroidal glycosides (
1
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Previously, various steroidal glycosides were reported from plants of
Cestrum species. However, phytochemical investigation has not been conducted on
Cestrum newellii. A systematic phytochemical investigation of the leaves of
C. newellii resulted in the isolation of eight novel steroidal glycosides (
1–
8), which were classified into three spirostanol glycosides (
1–
3), two furostanol glycosides (
4 and
5), two pseudofurostanol glycosides (
6 and
7), and one cholestane glycoside (
8). In addition, three known cholestane glycosides (
9–
11) were isolated and identified. The structures of the new compounds were determined based on spectroscopic data and chemical transformations. Compounds
1 and
2 are spirostanol glycosides having hydroxy groups at C-2, C-3, C-12, and C-24 of the aglycone moiety. Although
C. newellii is known to be a poisonous plant, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2
H-tetrazolium bromide assay exhibited that none of the isolated compounds were cytotoxic to HL-60 human promyelocytic leukemia cells.
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