Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (1)

Search Parameters:
Keywords = preclinical orthostatic hemodynamic dysregulation

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
11 pages, 571 KiB  
Article
The Importance of Orthostatic Increase in Pulse Wave Velocity in the Diagnosis of Early Vascular Aging
by Victor Dorogovtsev, Dmitry Yankevich, Andrey Martyushev-Poklad, Ilya Borisov and Andrey V. Grechko
J. Clin. Med. 2024, 13(19), 5713; https://doi.org/10.3390/jcm13195713 - 25 Sep 2024
Cited by 2 | Viewed by 1401
Abstract
Background/Objectives: Vascular aging can be assessed by arterial stiffness measured through pulse wave velocity (PWV). Increased PWV predicts arterial hypertension, cardiovascular events and all-cause mortality. Detection of early signs of vascular aging remains an unmet problem. To search for the most sensitive [...] Read more.
Background/Objectives: Vascular aging can be assessed by arterial stiffness measured through pulse wave velocity (PWV). Increased PWV predicts arterial hypertension, cardiovascular events and all-cause mortality. Detection of early signs of vascular aging remains an unmet problem. To search for the most sensitive markers for the early increase in vascular stiffness in a healthy population. Methods: One-hundred and twenty healthy subjects were divided in three equal age groups: <30 years, 30–45 years and >45 years. Head-up tilt test (HUTT) protocol was applied, providing a standardized hydrostatic column height. PWV at the brachial–ankle artery site (baPWV) was measured using a multichannel sphygmomanometer ABI System 100 PWV in three positions: in the baseline horizontal (supine) position—baPWVb; during the head tilt-up with an individual angle of inclination—baPWVt; and when returning to supine. Results: The most sensitive marker of early stiffness increase in a healthy population is the relative orthostatic increase in baPWV, ΔbaPWV/baPWVb, where ΔbaPWV = baPWVt − baPWVb. The significance of differences in this parameter between the young and elderly groups reached p = 0.000075 and p = 0.000006, respectively. Conclusions: The proposed index ΔbaPWV/baPWVb can be considered as a promising sensitive early biomarker of vascular aging and as a potential effective indicator in cardiovascular prevention. A longitudinal cohort study is needed to confirm this assumption. Full article
(This article belongs to the Special Issue Advances in Vascular Aging)
Show Figures

Figure 1

Back to TopTop