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Keywords = phospha-aldol reaction

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56 pages, 57303 KiB  
Review
Catalytic Asymmetric Synthesis of C-Chiral Phosphonates
by Anastasy O. Kolodiazhna and Oleg I. Kolodiazhnyi
Symmetry 2022, 14(9), 1758; https://doi.org/10.3390/sym14091758 - 23 Aug 2022
Cited by 15 | Viewed by 4166
Abstract
The current review is devoted to the achievements in the development of methods for the catalytic asymmetric synthesis of phosphonates containing a chiral center in the side chain. C-chiral phosphonates are widely represented among natural compounds with various biological activities as insecticides, herbicides, [...] Read more.
The current review is devoted to the achievements in the development of methods for the catalytic asymmetric synthesis of phosphonates containing a chiral center in the side chain. C-chiral phosphonates are widely represented among natural compounds with various biological activities as insecticides, herbicides, antibiotics, and bioregulators. Synthetic representatives of this class have found practical application as biologically active compounds. The review summarizes methods of asymmetric metal complex catalysis and organocatalysis as applied to such reactions as phospha-aldol reaction, two-component and three-component phospha-Mannich reaction, phospha-Michael reaction, as well as hydrogenation of unsaturated phosphonates and phosphine oxides, ketophosphonates, and iminophosphonates. Methods for the asymmetric hydride reduction of C=X phosphonates (X=O, S, NR) are also discussed in detail. The review presents updated literature reports, as well as original research by the author. Full article
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