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Keywords = palmar erythema

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18 pages, 2066 KiB  
Review
Cutaneous Manifestations of Liver Cirrhosis: Clinical Significance and Diagnostic Implications
by Rita Kamoua, Rebecca Reese, Risha Annamraju, Tian Chen, Colleen Doyle, Adriana Parella, Amelia Liu, Yazan Abboud, Craig Rohan and Jeffrey B. Travers
Livers 2025, 5(3), 37; https://doi.org/10.3390/livers5030037 - 15 Aug 2025
Abstract
Liver cirrhosis, a progressive and often irreversible condition, exerts widespread systemic effects, with the skin frequently serving as a visible window into the extent of hepatic dysfunction. Cutaneous manifestations, such as spider angiomas, palmar erythema, jaundice, and pruritus, not only reflect underlying pathophysiologic [...] Read more.
Liver cirrhosis, a progressive and often irreversible condition, exerts widespread systemic effects, with the skin frequently serving as a visible window into the extent of hepatic dysfunction. Cutaneous manifestations, such as spider angiomas, palmar erythema, jaundice, and pruritus, not only reflect underlying pathophysiologic changes but also serve as important, non-invasive diagnostic and prognostic markers of disease severity. Early detection of such cutaneous findings may allow for early treatment, optimize patient management, and improve outcomes. This review addresses the various cutaneous manifestations of liver cirrhosis, their pathogenesis, and their prognostic and diagnostic importance, emphasizing the need for heightened clinical awareness of the improvement in patient care. Full article
(This article belongs to the Special Issue Liver Fibrosis: Mechanisms, Targets, Assessment and Treatment)
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12 pages, 1268 KiB  
Review
Cabozantinib Cutaneous Toxicity—Comprehensive Review
by Cristina Violeta Tutunaru, Dragos Ovidiu Alexandru, Sanda Amelia Dracea, Loredana Ungureanu, Liliana Gabriela Popa and Cristina Beiu
Life 2025, 15(1), 72; https://doi.org/10.3390/life15010072 - 9 Jan 2025
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Abstract
Background: In the context of modern cancer therapy, the management of adverse effects of systemic therapies can lead to the avoidance of underdosing and withdrawal and increases in the quality of the therapeutic act and the quality of life. This review offers an [...] Read more.
Background: In the context of modern cancer therapy, the management of adverse effects of systemic therapies can lead to the avoidance of underdosing and withdrawal and increases in the quality of the therapeutic act and the quality of life. This review offers an overview of the skin-related toxicities associated with Cabozantinib, a multikinase inhibitor (MKI) that is approved for treating advanced kidney cancer, hepatocellular carcinoma, and medullary thyroid cancer. It covers the most common dermatological side effects, such as palmar–plantar erythrodysesthesia, stomatitis, hair alterations, xerosis, scrotal erythema, and subungual splinter hemorrhages. Additionally, this review includes suggested preventive strategies and management approaches based on the severity of these adverse effects. Full article
(This article belongs to the Special Issue Multidisciplinary Management of Dermatology)
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