Search Results (3)

Mosaic loss of chromosome Y (mLOY) is a common ageing-related somatic event and has been previously associated with Alzheimer’s disease (AD). However, mLOY estimation from genotype microarray data only reflects the mLOY degree of subjects at the moment of DNA sampling. Therefore, mLOY phenotype associations with AD can be severely age-confounded in the context of genome-wide association studies. Here, we applied Mendelian randomisation to construct an age-independent mLOY polygenic risk score (mloy-PRS) using 114 autosomal variants. The mloy-PRS instrument was associated with an 80% increase in mLOY risk per standard deviation unit (p = 4.22 × 10⁻²⁰) and was orthogonal with age. We found that a higher genetic risk for mLOY was associated with faster progression to AD in men with mild cognitive impairment (hazard ratio (HR) = 1.23, p = 0.01). Importantly, mloy-PRS had no effect on AD conversion or risk in the female group, suggesting that these associations are caused by the inherent loss of the Y chromosome. Additionally, the blood mLOY phenotype in men was associated with increased cerebrospinal fluid levels of total tau and phosphorylated tau181 in subjects with mild cognitive impairment and dementia. Our results strongly suggest that mLOY is involved in AD pathogenesis. Full article

The global environment faces the issue of sustainability arising from the persistent growth rates in general production levels. Hence, there is the need to resolve the growth environment conflicts in order to enhance the sustainability of the current and future generations. This study presents the first empirical analysis on the dynamic impacts of non-renewable and renewable energy, total resource rents, population growth, human capital, and financial inclusion on environmental quality in Sub-Saharan Africa (SSA) with the conditioning roles of technological progress and income level. The empirical evidence is based on a two-step system generalized method of moments (SYS-GMM) with forward orthogonal deviations for 42 countries in the SSA region from 2004 to 2018. The following results are established from the empirical analyses. First, renewable energy emerges as a promoter of environmental quality through its reducing impacts on carbon emissions per capita (co2pc). Second, other regressors turn out to impede environmental quality by contributing to the surge in co2pc. Third, the robustness checks analyses, which consider different variants of carbon emissions as outcome variables, revealing that the main results are robust and empirically supported to explain the variations in the level of pollutants in the region. Fourth, the impacts of technological progress from both direct (unconditional) and interactive (conditional) angles mitigate co2pc while income promotes it. On the policy front, promoting investment in renewable energy and structuring human capital development plans to promote green growth are seen as sacrosanct towards achieving a sustainable environment in the region. Full article

Motion estimation is a low-level vision task that is especially relevant due to its wide range of applications in the real world. Many of the best motion estimation algorithms include some of the features that are found in mammalians, which would demand huge computational resources and therefore are not usually available in real-time. In this paper we present a novel bioinspired sensor based on the synergy between optical flow and orthogonal variant moments. The bioinspired sensor has been designed for Very Large Scale Integration (VLSI) using properties of the mammalian cortical motion pathway. This sensor combines low-level primitives (optical flow and image moments) in order to produce a mid-level vision abstraction layer. The results are described trough experiments showing the validity of the proposed system and an analysis of the computational resources and performance of the applied algorithms. Full article