Search Results (3)

Novel therapeutic delivery systems and delivery methods to the inner ear are necessary to treat hearing loss and inner ear disorders. However, numerous barriers exist to therapeutic delivery into the bone-encased and immune-privileged environment of the inner ear and cochlea, which makes treating inner ear disorders challenging. Nanoparticles (NPs) are a type of therapeutic delivery system that can be engineered for multiple purposes, and posterior semicircular canal (PSCC) infusion is a method to directly deposit them into the cochlea. We sought to assess PSCC infusion of gold NPs into the cochlea, including the NPs’ distribution and effect on cochlear mechanics. We performed optical coherence tomography (OCT) imaging to monitor PSCC infusion of gold NPs into the cochlear chambers. OCT imaging demonstrated that the infusion specifically targeted the perilymphatic spaces within the cochlea. We assessed cochlear mechanics by using OCT vibrometry to measure sound-evoked movements of the basilar membrane. We found no changes in cochlear mechanics between measurements at baseline, after the PSCC canalostomy, immediately after the infusion, and 1 h after the infusion of gold NPs (p > 0.05, paired t-test). These findings validate the PSCC infusion approach for perfusing the cochlear perilymphatic space with a nanoparticle delivery system. Thus, PSCC infusion of nanoparticles is a feasible therapeutic delivery technique for treating inner ear disorders while preserving residual cochlear function. Full article

Optical coherent detection is widely used for highly sensitive sensing applications, but nonlinearity issues pose challenges in accurately interpreting the system outputs. Most existing compensation methods require access to raw measurement data, making them not useful when only demodulated data are available. In this study, we propose a compensation method designed for direct application to demodulated data, effectively addressing the 1st and 2nd-order nonlinearities in both homodyne and heterodyne systems. The approach involves segmenting the distorted signal, fitting and removing baselines in each section, and averaging the resulting distortions to obtain precise distortion shapes. These shapes are then used to retrieve compensation parameters. Simulation shows that the proposed method can effectively reduce the deviation caused by the nonlinearities without using the raw data. Experimental results from a silicon-photonics-based homodyne laser Doppler vibrometry prove that this method has a similar performance as the conventional Heydemann correction method. Full article

In otology, visualization and vibratory analysis have been crucial to enhance the success of diagnosis and surgical operation. Optical coherence tomography (OCT) has been employed in otology to obtain morphological structure of tissues non-invasively, owing to the ability of measuring the entire region of tympanic membrane, which compensates the limitations of conventional methods. As a functional extension of OCT, Doppler OCT, which enables the measurement of the motion information with structural data of tissue, has been applied in otology. Over the years, Doppler OCT systems have been evolved in various forms to enhance the measuring sensitivity of phase difference. In this review, we provide representative algorithms of Doppler OCT and various applications in otology from preclinical analysis to clinical experiments and discuss future developments. Full article