Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (1)

Search Parameters:
Keywords = omega-3 sn-1(3)-monoacylglycerol

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
21 pages, 2597 KiB  
Article
Monoacylglycerol Form of Omega-3s Improves Its Bioavailability in Humans Compared to Other Forms
by Bernard Cuenoud, Isabelle Rochat, Maria Laura Gosoniu, Lenaick Dupuis, Evan Berk, Anke Jaudszus, Jochen G. Mainz, Gaudenz Hafen, Maurice Beaumont and Cristina Cruz-Hernandez
Nutrients 2020, 12(4), 1014; https://doi.org/10.3390/nu12041014 - 7 Apr 2020
Cited by 21 | Viewed by 5893
Abstract
Numerous benefits are attributed to omega-3 fatty acids (OM3) especially in cardiovascular health. However, bioavailability and clinical efficacy depend on numerous factors, including OM3 form, food matrix effects (especially the lipid content of the diet), and metabolic capacity. Here, we show in humans [...] Read more.
Numerous benefits are attributed to omega-3 fatty acids (OM3) especially in cardiovascular health. However, bioavailability and clinical efficacy depend on numerous factors, including OM3 form, food matrix effects (especially the lipid content of the diet), and metabolic capacity. Here, we show in humans that a “pre-digested” OM3-sn-1(3)-monoacylglycerol lipid structure (OM3-MAG) has a significantly greater absorption at high therapeutic doses (2.9 g/day) than the most commonly OM3-ethyl ester (3.1 g/day) form (used for the treatment of hypertriglyceridemia), and a comparable profile to other pre-digested OM3 free fatty acids (OM3-FFA) structure (3.2 g/day). Nutritional supplement doses of MAG resulted in similar increases in OM3 blood level, compared to OM3 triacylglycerols (OM3-TAG) supplements in obese subjects (1.2 g/day) under low fat diet, and in children with cystic fibrosis (1.0 g/day). These results suggest that both forms of pre-digested OM3-MAG and OM3-FFA are effectively absorbed and re-incorporated effectively into triacylglycerols inside the enterocytes, before being exported into the chylomicrons lipid transport system. The pre-digested OM3-MAG might provide a more effective therapy in severe cardiovascular conditions where high doses of OM3 are required and a low-fat diet is indicated, which limited digestive lipase activity. Full article
Show Figures

Graphical abstract

Back to TopTop