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Keywords = methoxymethylgermacranolides

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12 pages, 1732 KB  
Article
New 11-Methoxymethylgermacranolides from the Whole Plant of Carpesium divaricatum
by Tao Zhang, Haixin Zhang, Chunyu Lin, Lu Fu and Zhongmei Zou
Molecules 2022, 27(18), 5991; https://doi.org/10.3390/molecules27185991 - 14 Sep 2022
Cited by 1 | Viewed by 2011
Abstract
Eight new 11-methoxymethylgermacranolides (18) were isolated from the ethanol extract of the whole plant of Carpesium divaricatum. The planar structures and relative configurations of the new compounds were determined by detailed spectroscopic analysis. The absolute configuration of 1 [...] Read more.
Eight new 11-methoxymethylgermacranolides (18) were isolated from the ethanol extract of the whole plant of Carpesium divaricatum. The planar structures and relative configurations of the new compounds were determined by detailed spectroscopic analysis. The absolute configuration of 1 was established by electronic circular dichroism (ECD) spectrum and X-ray crystallographic analysis, and the stereochemistry of the new compounds 28 were determined by similar ECD data with 1. The absolute configurations of 5 and 7 were further confirmed by using quantum chemical electronic circular dichroism (ECD) calculations. Compound 4 exhibited weak cytotoxicity against MCF-7 cells. Compound 8 could potently decrease PGE2 productions in LPS-induced RAW 264.7 cells. Full article
(This article belongs to the Special Issue Natural Secondary Metabolites II)
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