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Keywords = metallophosphonates

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17 pages, 680 KiB  
Review
Synthesis of DNA/RNA and Their Analogs via Phosphoramidite and H-Phosphonate Chemistries
by Subhadeep Roy and Marvin Caruthers
Molecules 2013, 18(11), 14268-14284; https://doi.org/10.3390/molecules181114268 - 18 Nov 2013
Cited by 99 | Viewed by 19761
Abstract
The chemical synthesis of DNA and RNA is universally carried out using nucleoside phosphoramidites or H-phosphonates as synthons. This review focuses on the phosphorus chemistry behind these synthons and how it has been developed to generate procedures whereby yields per condensation approach 100% [...] Read more.
The chemical synthesis of DNA and RNA is universally carried out using nucleoside phosphoramidites or H-phosphonates as synthons. This review focuses on the phosphorus chemistry behind these synthons and how it has been developed to generate procedures whereby yields per condensation approach 100% with very few side products. Additionally the synthesis and properties of certain DNA and RNA analogs that are modified at phosphorus will also be discussed. These analogs include boranephosphonates, metallophosphonates, and alkylboranephosphines. Full article
(This article belongs to the Special Issue Organophosphorus Chemistry)
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