Search Results (4)

Background: A knowledge gap exists on population understanding and perspectives of menopause. To better support females, it is important to understand different population groups’ perceived knowledge of and attitudes towards menopause. This study explored perceived knowledge of menopause, awareness of menopausal symptoms, perceived negative impacts of menopause on females’ lives, and attitudes towards menopause. Methods: A national cross-sectional survey (n = 1020) was conducted with residents in Wales aged 16+ years as part of a larger population panel using a multi-method approach (online, telephone, and face-to-face), stratified by NHS health board area, age, sex, deprivation, and ethnicity. Questions on menopause were developed by the research team. Results: Nearly a third (31.1%) of participants reported having low knowledge of menopause, with younger age groups and males reporting the lowest knowledge. Hot flushes were the most recognised menopause symptom (92.2%). The symptom with the greatest gap in awareness between age groups, sexes, and deprivation quintiles was problems with memory or concentration. Most participants perceived menopause to have a large negative impact on females’ mental health (76.1%), working life (69.7%) and physical health (69.6%). Females and 30–49-year-olds were more likely to perceive large negative impacts across all three domains. Most participants (77.8%) agreed that more public discussion is needed on menopause to increase understanding. The greatest support for increasing public discussion was found amongst females and people aged 30–49 years old. Conclusions: At a population level, perceived knowledge of menopause and associated symptoms and perceived impacts on females’ lives varied across socio-demographic groups. While males were less knowledgeable than females, most males perceived negative impacts on females’ lives and agreed with action to improve the menopausal environment. Increasing knowledge in those who experience menopause and in those who support those who experience menopause could help females have a more positive transition process. Full article

This research is focused on the water usage patterns in two student residences—one for male students (Residence I) and the other for female students (Residence II). Surveys and measurements of flushing cisterns, taps, and shower flows were conducted to understand water use behaviors. Scenario 1 proposed replacing washbasin and kitchen taps and installing flow reducers in showers, while Scenario 2 combined Scenario 1 with a rainwater harvesting system for recharging flush cisterns. Showers were found to be the most water-consuming devices, accounting for 46% and 61.41% of water consumption in Residences I and II, respectively, followed by kitchen taps (31.51% in Residence I and 11.52% in Residence II). The flushing cistern consumption was 7.02% in Residence I and 13.22% in Residence II. The implementation of Scenario 1 anticipates a 13% reduction in total water consumption in Residence I and a 10% reduction in Residence II. The reduction in hot water consumption would result in a decrease in annual electricity consumption by 27.8% and 23.06% in Residence I and II, respectively. With the implementation of Scenario 2, the total potential water savings for Residence I could increase to 19.98%, and for Residence II, it could rise to 23.17%. The proposed measures aim to enhance water sustainability in these buildings and can be replicated elsewhere. Full article

Panic disorder by definition is an anxiety disorder of unexpected and repeated episodes of intense fear. Panic attacks are usually diagnosed by four or more of a set of symptoms that include palpitations, sweating, trembling, shortness of breath, chest pain, nausea, dizziness, and hot flushes. They usually interfere with daily life situations and also interfere with education. Hence, the aim of this study was to assess the prevalence of panic attacks, their symptoms, and triggering factors among dental students in Riyadh, Saudi Arabia. Data were collected from 394 students using a structured and validated questionnaire. The prevalence of panic attacks among dental students in Riyadh, Saudi Arabia, was 42.9%. Most of the participants who experienced higher episodes of panic attacks were females (53.4%) when compared to males (24.5%). Third year students displayed greater (58.3%) episodes of panic attacks compared to their respective counterparts. The most reported symptom of panic attacks was rapid or pounding heartbeat followed by breathlessness, chest pain, and shaking or trembling. It was also noted that most of the participants (63.31%) encountered a panic attack for the first time after joining dental school. The situations where dental students frequently experienced panic attacks were during exams, clinic procedures, giving presentations, and especially while under a lot of stress. The high occurrence of panic attacks among dental students highlights the importance of providing support programs and implementing preventive measures to help students, particularly those who are most susceptible to higher levels of these psychological conditions. Dental students experiencing panic attacks should be provided with necessary counseling sessions or psychiatric consultation in order to overcome such scenarios. Dental schools should consider these findings when planning the dental curriculum. Hence, the role of the faculty members is essential in these situations to provide support for the affected students. Full article

Hot flushes are best-known for affecting menopausal women, but men who undergo life-saving castration due to androgen-sensitive prostate cancer also suffer from these vasomotor symptoms. Estrogen deficiency in these patients is a direct consequence of androgen deprivation, because estrogens (notably 17β-estradiol, E₂) are produced from testosterone. Although estrogens alleviate hot flushes in these patients, they also cause adverse systemic side effects. Because only estrogens can provide mitigation of hot flushes on the basis of current clinical practices, there is an unmet need for an effective and safe pharmacotherapeutic intervention that would also greatly enhance patient adherence. To this end, we evaluated treatment of orchidectomized (ORDX) rats with 10β, 17β-dihydroxyestra-1,4-dien-3-one (DHED), a brain-selective bioprecursor prodrug of E₂. A pilot pharmacokinetic study using oral administration of DHED to these animals revealed the formation of E₂ in the brain without the appearance of the hormone in the circulation. Therefore, DHED treatment alleviated androgen deprivation-associated hot flushes without peripheral impact in the ORDX rat model. Concomitantly, we showed that DHED-derived E₂ induced progesterone receptor gene expression in the hypothalamus without stimulating galanin expression in the anterior pituitary, further indicating the lack of systemic estrogen exposure upon oral treatment with DHED. Full article