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Keywords = magnetic multicore particles (MCP)

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18 pages, 4824 KiB  
Article
Tailored Magnetic Multicore Nanoparticles for Use as Blood Pool MPI Tracers
by Harald Kratz, Azadeh Mohtashamdolatshahi, Dietmar Eberbeck, Olaf Kosch, Frank Wiekhorst, Matthias Taupitz, Bernd Hamm, Nicola Stolzenburg and Jörg Schnorr
Nanomaterials 2021, 11(6), 1532; https://doi.org/10.3390/nano11061532 - 10 Jun 2021
Cited by 18 | Viewed by 3913
Abstract
For the preclinical development of magnetic particle imaging (MPI) in general, and the exploration of possible new clinical applications of MPI in particular, tailored MPI tracers with surface properties optimized for the intended use are needed. Here we present the synthesis of magnetic [...] Read more.
For the preclinical development of magnetic particle imaging (MPI) in general, and the exploration of possible new clinical applications of MPI in particular, tailored MPI tracers with surface properties optimized for the intended use are needed. Here we present the synthesis of magnetic multicore particles (MCPs) modified with polyethylene glycol (PEG) for use as blood pool MPI tracers. To achieve the stealth effect the carboxylic groups of the parent MCP were activated and coupled with pegylated amines (mPEG-amines) with different PEG-chain lengths from 2 to 20 kDa. The resulting MCP-PEG variants with PEG-chain lengths of 10 kDa (MCP-PEG10K after one pegylation step and MCP-PEG10K2 after a second pegylation step) formed stable dispersions and showed strong evidence of a successful reaction of MCP and MCP-PEG10K with mPEG-amine with 10 kDa, while maintaining their magnetic properties. In rats, the mean blood half-lives, surprisingly, were 2 and 62 min, respectively, and therefore, for MCP-PEG10K2, dramatically extended compared to the parent MCP, presumably due to the higher PEG density on the particle surface, which may lead to a lower phagocytosis rate. Because of their significantly extended blood half-life, MCP-PEG10K2 are very promising as blood pool tracers for future in vivo cardiovascular MPI. Full article
(This article belongs to the Special Issue Novel Magnetic Nanoparticles: Synthesis and Biomedical Applications)
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17 pages, 4892 KiB  
Article
MPI Phantom Study with A High-Performing Multicore Tracer Made by Coprecipitation
by Harald Kratz, Azadeh Mohtashamdolatshahi, Dietmar Eberbeck, Olaf Kosch, Ralf Hauptmann, Frank Wiekhorst, Matthias Taupitz, Bernd Hamm and Jörg Schnorr
Nanomaterials 2019, 9(10), 1466; https://doi.org/10.3390/nano9101466 - 16 Oct 2019
Cited by 20 | Viewed by 4185
Abstract
Magnetic particle imaging (MPI) is a new imaging technique that detects the spatial distribution of magnetic nanoparticles (MNP) with the option of high temporal resolution. MPI relies on particular MNP as tracers with tailored characteristics for improvement of sensitivity and image resolution. For [...] Read more.
Magnetic particle imaging (MPI) is a new imaging technique that detects the spatial distribution of magnetic nanoparticles (MNP) with the option of high temporal resolution. MPI relies on particular MNP as tracers with tailored characteristics for improvement of sensitivity and image resolution. For this reason, we developed optimized multicore particles (MCP 3) made by coprecipitation via synthesis of green rust and subsequent oxidation to iron oxide cores consisting of a magnetite/maghemite mixed phase. MCP 3 shows high saturation magnetization close to that of bulk maghemite and provides excellent magnetic particle spectroscopy properties which are superior to Resovist® and any other up to now published MPI tracers made by coprecipitation. To evaluate the MPI characteristics of MCP 3 two kinds of tube phantoms were prepared and investigated to assess sensitivity, spatial resolution, artifact severity, and selectivity. Resovist® was used as standard of comparison. For image reconstruction, the regularization factor was optimized, and the resulting images were investigated in terms of quantifying of volumes and iron content. Our results demonstrate the superiority of MCP 3 over Resovist® for all investigated MPI characteristics and suggest that MCP 3 is promising for future experimental in vivo studies. Full article
(This article belongs to the Special Issue Nanomaterials for Contrast Agent and Biomedical Imaging)
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