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Keywords = local anaesthetic/antiseptic treatment

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12 pages, 542 KB  
Communication
The Treatment of Contagious Ecthyma in Lambs with a Local Anaesthetic/Antiseptic Wound Formulation Lowers Serum Amyloid A Responses
by Aurora Ortín, Sergio Villanueva-Saz, Delia Lacasta, Peter Andrew Windsor, Antonio Fernández, Pablo Quilez, Hector Ruiz, Alex Gómez, David Guallar and Marta Ruiz de Arcaute
Animals 2026, 16(1), 17; https://doi.org/10.3390/ani16010017 - 20 Dec 2025
Viewed by 56
Abstract
Contagious ecthyma (CE) is a widespread, highly contagious zoonotic skin disease of small ruminants caused by the Orf virus (ORFV), leading to substantial economic losses and welfare concerns. There is no specific treatment, with topical antiseptics and oral or parenteral antibiotics often administered [...] Read more.
Contagious ecthyma (CE) is a widespread, highly contagious zoonotic skin disease of small ruminants caused by the Orf virus (ORFV), leading to substantial economic losses and welfare concerns. There is no specific treatment, with topical antiseptics and oral or parenteral antibiotics often administered for preventing secondary infections, risking antimicrobial resistance. This study assessed the effect of treating CE in lambs with an antibiotic-free topical anaesthetic/antiseptic formulation (Tri-Solfen®; T-S; Medical Ethics, Australia/MultiSolfen®; M-S; Dechra, UK). Serum amyloid A (SAA), a marker of systemic inflammation, was measured in both experimentally and naturally infected lambs allocated to treated and untreated groups. Samples were collected prior to (T0) and at 2 (T2), 7 (T7) and 14 (T14) days post-treatment in experimentally infected lambs and at T0, 10 (T10) and 20 (T20) days post-treatment in naturally affected lambs. In the experimental infection, SAA concentrations were lower in the treated group than in controls at T7 and significantly lower at T14. In the natural outbreak, SAA concentrations significantly decreased over time in the treated group, with a consistent trend toward lower values than in controls. These findings indicate that this therapeutic formulation reduces systemic inflammatory responses in lambs affected by CE, supporting its use as an alternative to antibiotics. Full article
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14 pages, 961 KB  
Article
Use of a Local Anaesthetic/Antiseptic Formulation for the Treatment of Lambs Experimentally Infected with Orf Virus
by Delia Lacasta, Marina Ríos, Marta Ruiz de Arcaute, Aurora Ortín, Juan José Ramos, Sergio Villanueva-Saz, María Teresa Tejedor, Héctor Ruiz, Marta Borobia, Ramsés Reina, Alex Gómez, Teresa Navarro and Peter Andrew Windsor
Animals 2023, 13(18), 2962; https://doi.org/10.3390/ani13182962 - 19 Sep 2023
Cited by 2 | Viewed by 2473
Abstract
Contagious ecthyma is a highly transmissible eruptive viral disease of the skin and mucosa of sheep and goats distributed worldwide. The treatment of orf lesions is usually based on the use of antiseptics and antibiotics for the management of presumptive secondary infections, increasing [...] Read more.
Contagious ecthyma is a highly transmissible eruptive viral disease of the skin and mucosa of sheep and goats distributed worldwide. The treatment of orf lesions is usually based on the use of antiseptics and antibiotics for the management of presumptive secondary infections, increasing risks of antimicrobial resistance. The wound dressing formulation Tri-Solfen® (TS) containing two local anaesthetics (lignocaine and bupivacaine), adrenaline and an antiseptic (cetrimide) in a gel formulation has been demonstrated to reduce suffering and enhance recovery in cattle and buffalo with oral and skin lesions due to foot-and-mouth disease virus infection and reduced the orf viral load in lambs. In the present study, experimental infection with the orf virus was conducted in 50 newborn lambs and 25 animals were treated after the presence of the first lesions with TS and repeated three days later. Daily clinical examination, haematological, serological, biomolecular and post-mortem analyses were conducted during 34 days after treatment. Results indicated that treatment had no effect on weight gain and clinical progression of the lesions. It was determined that seroconversion after experimental infection occurs 34 days after infection and suggested that the deep basal epithelial location of the orf lesions may have prevented the therapy from having altered the clinical course. Full article
(This article belongs to the Special Issue The Pathway to Solutions: Diagnosing and Treating Viral Diseases of Small Ruminants)
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