Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (1)

Search Parameters:
Keywords = isonaringin

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
15 pages, 2548 KiB  
Article
Citrus Flavanone Narirutin, In Vitro and In Silico Mechanistic Antidiabetic Potential
by Ashraf Ahmed Qurtam, Hamza Mechchate, Imane Es-safi, Mohammed Al-zharani, Fahd A. Nasr, Omar M. Noman, Mohammed Aleissa, Hamada Imtara, Abdulmalik M. Aleissa, Mohamed Bouhrim and Ali S. Alqahtani
Pharmaceutics 2021, 13(11), 1818; https://doi.org/10.3390/pharmaceutics13111818 - 31 Oct 2021
Cited by 29 | Viewed by 4253
Abstract
Citrus fruits and juices have been studied extensively for their potential involvement in the prevention of various diseases. Flavanones, the characteristic polyphenols of citrus species, are the primarily compounds responsible for these studied health benefits. Using in silico and in vitro methods, we [...] Read more.
Citrus fruits and juices have been studied extensively for their potential involvement in the prevention of various diseases. Flavanones, the characteristic polyphenols of citrus species, are the primarily compounds responsible for these studied health benefits. Using in silico and in vitro methods, we are exploring the possible antidiabetic action of narirutin, a flavanone family member. The goal of the in silico research was to anticipate how narirutin would interact with eight distinct receptors implicated in diabetes control and complications, namely, dipeptidyl-peptidase 4 (DPP4), protein tyrosine phosphatase 1B (PTP1B), free fatty acid receptor 1 (FFAR1), aldose reductase (AldR), glycogen phosphorylase (GP), alpha-amylase (AAM), peroxisome proliferator-activated receptor gamma (PPAR-γ), alpha-glucosidase (AGL), while the in vitro study looked into narirutin’s possible inhibitory impact on alpha-amylase and alpha-glucosidase. The results indicate that the studied citrus flavanone interacted remarkably with most of the receptors and had an excellent inhibitory activity during the in vitro tests suggesting its potent role among the different constituent of the citrus compounds in the management of diabetes and also its complications. Full article
(This article belongs to the Special Issue The Role of Natural Products on Diabetes Mellitus Treatment)
Show Figures

Graphical abstract

Back to TopTop