Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (1)

Search Parameters:
Keywords = interrupted Ugi reactions

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
17 pages, 3138 KiB  
Article
Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines
by Ubaldina Galli, Rejdia Hysenlika, Fiorella Meneghetti, Erika Del Grosso, Sveva Pelliccia, Ettore Novellino, Mariateresa Giustiniano and Gian Cesare Tron
Molecules 2019, 24(10), 1959; https://doi.org/10.3390/molecules24101959 - 21 May 2019
Cited by 3 | Viewed by 4324
Abstract
A novel one-pot multicomponent reaction to synthesize substituted imidazopyrazines is described. In brief, 1H-(imidazol-5-yl)-N-substituted methanamines react with aldehydes and isocyanides in methanol at room temperature to give imidazopyrazine derivatives in excellent yields. The imidazole nitrogen atom was able to [...] Read more.
A novel one-pot multicomponent reaction to synthesize substituted imidazopyrazines is described. In brief, 1H-(imidazol-5-yl)-N-substituted methanamines react with aldehydes and isocyanides in methanol at room temperature to give imidazopyrazine derivatives in excellent yields. The imidazole nitrogen atom was able to intercept the nascent nitrilium ion, channeling the reaction toward to the sole formation of imidazopyrazines, suppressing the competitive formation of other possible side products deriving from the reaction with the high-energy nitrilium ion. The number of examples and the variability of the nature of isocyanides, aldehydes, and amine components herein employed, witness the robustness of this novel methodology. Full article
(This article belongs to the Special Issue Enabling Chemical Technologies in Medicinal Chemistry)
Show Figures

Figure 1

Back to TopTop