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Keywords = integrin beta 6 (INGB6)

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18 pages, 1691 KiB  
Review
Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment
by Ewa Brzozowska and Sameer Deshmukh
Int. J. Mol. Sci. 2022, 23(20), 12346; https://doi.org/10.3390/ijms232012346 - 15 Oct 2022
Cited by 27 | Viewed by 10354
Abstract
Integrins are necessary for cell adhesion, migration, and positioning. Essential for inducing signalling events for cell survival, proliferation, and differentiation, they also trigger a variety of signal transduction pathways involved in mediating invasion, metastasis, and squamous-cell carcinoma. Several recent studies have demonstrated that [...] Read more.
Integrins are necessary for cell adhesion, migration, and positioning. Essential for inducing signalling events for cell survival, proliferation, and differentiation, they also trigger a variety of signal transduction pathways involved in mediating invasion, metastasis, and squamous-cell carcinoma. Several recent studies have demonstrated that the up- and down-regulation of the expression of αv and other integrins can be a potent marker of malignant diseases and patient prognosis. This review focuses on an arginine-glycine-aspartic acid (RGD)-dependent integrin αVβ6, its biology, and its role in healthy humans. We examine the implications of αVβ6 in cancer progression and the promotion of epithelial-mesenchymal transition (EMT) by contributing to the activation of transforming growth factor beta TGF-β. Although αvβ6 is crucial for proper function in healthy people, it has also been validated as a target for cancer treatment. This review briefly considers aspects of targeting αVβ6 in the clinic via different therapeutic modalities. Full article
(This article belongs to the Special Issue Targeted Therapies and Molecular Methods in Cancer)
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