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Keywords = imparted dose at the rodent’s surface

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13 pages, 1151 KiB  
Article
Dosimetric Evaluation in Micro-CT Studies Used in Preclinical Molecular Imaging
by Alexis N. Rueda, César Ruiz-Trejo, Eduardo López-Pineda, Mario E. Romero-Piña and Luis A. Medina
Appl. Sci. 2021, 11(17), 7930; https://doi.org/10.3390/app11177930 - 27 Aug 2021
Cited by 2 | Viewed by 2481
Abstract
In microCT imaging, there is a close relationship between the dose of radiation absorbed by animals and the image quality, or spatial resolution. Although the radiation levels used in these systems are generally non-lethal, they can induce cellular or molecular alterations that affect [...] Read more.
In microCT imaging, there is a close relationship between the dose of radiation absorbed by animals and the image quality, or spatial resolution. Although the radiation levels used in these systems are generally non-lethal, they can induce cellular or molecular alterations that affect the experimental results. Here, we describe a dosimetric characterization of the different image acquisition modalities used by the microCT unit of the Albira microPET/SPECT/CT scanner, which is a widely used multimodal imaging system in preclinical research. The imparted dose at the animal surface (IDS) was estimated based on Boone’s polynomial interpolation method and experimental measurements using an ionization chamber and thermoluminescent dosimeters. The results indicated that the imparted dose at surface level delivered to the mice was in the 30 to 300 mGy range. For any combination of current (0.2 or 0.4 mA) and voltage (35 or 45 kV), in the Standard, Good, and Best image acquisition modalities, the dose imparted at surface level in rodents was below its threshold of deterministic effects (250 mGy); however, the High Res modality was above that threshold. Full article
(This article belongs to the Special Issue Applications to Biophysics and Medical Physics)
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