Open AccessReview
Novel Therapeutic Agents for Management of Diabetes Mellitus: A Hope for Drug Designing against Diabetes Mellitus
by
Ahmed M. E. Elkhalifa, Mehak Nazar, Sofi Imtiyaz Ali, Ibraq Khursheed, Syed Taifa, Muzafar Ahmad Mir, Iqra Hussain Shah, Masood Malik, Zahid Ramzan, Shubeena Ahad, Nusrat Bashir, Elham Elamin, Elsharif A. Bazie, Elsadig Mohamed Ahmed, Majed Mowanes Alruwaili, Ammar W. Baltoyour, Abdullah Salah Alarfaj, Ibrahim Ali Al Bataj, Abdullah M. A. Arabe and Showkat Ul Nabi
Cited by 20 | Viewed by 7580
Abstract
Diabetes mellitus (DM) is characterized by an absolute decline in insulin secretion and peripheral resistance and is the most prevalent metabolic and endocrine disorder. However, the pathogenesis of DM also includes adipocyte insulin resistance, increased glucagon secretion, increased renal glomerular glucose absorption, and
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Diabetes mellitus (DM) is characterized by an absolute decline in insulin secretion and peripheral resistance and is the most prevalent metabolic and endocrine disorder. However, the pathogenesis of DM also includes adipocyte insulin resistance, increased glucagon secretion, increased renal glomerular glucose absorption, and neurotransmitter dysfunction. Although there is a wide spectrum of therapeutics available for glycemic control, owing to the identification of various pathogenic determinants of DM, management of DM remains challenging and complex. Current therapeutic interventions against DM focus mostly on glycemic control without considering the other pathological determinants that eventually lead to treatment failure and the progression of DM. Furthermore, long-term use of these conventionally available anti-diabetic drugs leads to various side effects, henceforth development of novel drugs against DM remains an unending search strategy for researchers. Various studies conducted in various parts of the world have proposed that these novel therapeutic interventions target multiple and alternate pathogenic hotspots involved in DM. The current review article discusses novel therapeutic options that hold particular promise to support their safety and discuss the side effects resulting from their use so that these novel candidate drugs can be effectively fabricated into potential drugs for the treatment of DM.
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