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Keywords = idoxuridine (IDU)

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16 pages, 306 KiB  
Review
Antiviral Activity of 4'-thioIDU and Thymidine Analogs against Orthopoxviruses
by Mark N. Prichard and Earl R. Kern
Viruses 2010, 2(9), 1968-1983; https://doi.org/10.3390/v2091968 - 16 Sep 2010
Cited by 10 | Viewed by 6908
Abstract
The search for effective therapies for orthopoxvirus infections has identified diverse classes of molecules with antiviral activity. Pyrimidine analogs, such as 5-iodo-2'-deoxyuridine (idoxuridine, IDU) were among the first compounds identified with antiviral activity against a number of orthopoxviruses and have been reported to [...] Read more.
The search for effective therapies for orthopoxvirus infections has identified diverse classes of molecules with antiviral activity. Pyrimidine analogs, such as 5-iodo-2'-deoxyuridine (idoxuridine, IDU) were among the first compounds identified with antiviral activity against a number of orthopoxviruses and have been reported to be active both in vitro and in animal models of infection. More recently, additional analogs have been reported to have improved antiviral activity against orthopoxviruses including several derivatives of deoxyuridine with large substituents in the 5 position, as well as analogs with modifications in the deoxyribose moiety including (north)-methanocarbathymidine, and 5-iodo-4'-thio-2'-deoxyuridine (4'-thioIDU). The latter molecule has proven to have good antiviral activity against the orthopoxviruses both in vitro and in vivo and has the potential to be an effective therapy in humans. Full article
(This article belongs to the Special Issue Antivirals Against Poxviruses)
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18 pages, 859 KiB  
Review
Historical Perspectives in the Development of Antiviral Agents Against Poxviruses
by Erik De Clercq
Viruses 2010, 2(6), 1322-1339; https://doi.org/10.3390/v2061322 - 14 Jun 2010
Cited by 36 | Viewed by 10240
Abstract
The poxvirus vaccinia virus (VV) served as the model virus for which the first antivirals, the thiosemicarbazones, were identified. This dates back to 1950; and, although there is at present no single antiviral drug specifically licensed for the chemotherapy or -prophylaxis of poxvirus [...] Read more.
The poxvirus vaccinia virus (VV) served as the model virus for which the first antivirals, the thiosemicarbazones, were identified. This dates back to 1950; and, although there is at present no single antiviral drug specifically licensed for the chemotherapy or -prophylaxis of poxvirus infections, numerous candidate compounds have been described over the past 50 years. These compounds include interferon and inducers thereof (i.e., polyacrylic acid), 5-substituted 2’-deoxyuridines (i.e., idoxuridine), IMP dehydrogenase inhibitors, S-adenosylhomocysteine hydrolase inhibitors, acyclic nucleoside phosphonates (such as cidofovir) and alkoxyalkyl prodrugs thereof (such as CMX001), viral egress inhibitors (such as tecovirimat), and cellular kinase inhibitors (such as imatinib). Full article
(This article belongs to the Special Issue Antivirals Against Poxviruses)
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