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Keywords = hollow fibre membrane oxygenator

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16 pages, 2150 KiB  
Article
Extracorporeal Hyperoxygenation Therapy (EHT) for Carbon Monoxide Poisoning: In-Vitro Proof of Principle
by Niklas B. Steuer, Peter C. Schlanstein, Anke Hannig, Stephan Sibirtsev, Andreas Jupke, Thomas Schmitz-Rode, Rüdger Kopp, Ulrich Steinseifer, Georg Wagner and Jutta Arens
Membranes 2022, 12(1), 56; https://doi.org/10.3390/membranes12010056 - 31 Dec 2021
Cited by 6 | Viewed by 3317
Abstract
Carbon monoxide (CO) poisoning is the leading cause of poisoning-related deaths globally. The currently available therapy options are normobaric oxygen (NBO) and hyperbaric oxygen (HBO). While NBO lacks in efficacy, HBO is not available in all areas and countries. We present a novel [...] Read more.
Carbon monoxide (CO) poisoning is the leading cause of poisoning-related deaths globally. The currently available therapy options are normobaric oxygen (NBO) and hyperbaric oxygen (HBO). While NBO lacks in efficacy, HBO is not available in all areas and countries. We present a novel method, extracorporeal hyperoxygenation therapy (EHT), for the treatment of CO poisoning that eliminates the CO by treating blood extracorporeally at elevated oxygen partial pressure. In this study, we proof the principle of the method in vitro using procine blood: Firstly, we investigated the difference in the CO elimination of a hollow fibre membrane oxygenator and a specifically designed batch oxygenator based on the bubble oxygenator principle at elevated pressures (1, 3 bar). Secondly, the batch oxygenator was redesigned and tested for a broader range of pressures (1, 3, 5, 7 bar) and temperatures (23, 30, 37 °C). So far, the shortest measured carboxyhemoglobin half-life in the blood was 21.32 min. In conclusion, EHT has the potential to provide an easily available and effective method for the treatment of CO poisoning. Full article
(This article belongs to the Special Issue Membrane based Materials for Artificial Organs)
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