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Keywords = fijiolides

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13 pages, 813 KiB  
Article
New Benzoxazine Secondary Metabolites from an Arctic Actinomycete
by Kyuho Moon, Chan-Hong Ahn, Yoonho Shin, Tae Hyung Won, Keebeom Ko, Sang Kook Lee, Ki-Bong Oh, Jongheon Shin, Seung-Il Nam and Dong-Chan Oh
Mar. Drugs 2014, 12(5), 2526-2538; https://doi.org/10.3390/md12052526 - 30 Apr 2014
Cited by 42 | Viewed by 8240
Abstract
Two new secondary metabolites, arcticoside (1) and C-1027 chromophore-V (2), were isolated along with C-1027 chromophore-III and fijiolides A and B (35) from a culture of an Arctic marine actinomycete Streptomyces strain. The chemical structures [...] Read more.
Two new secondary metabolites, arcticoside (1) and C-1027 chromophore-V (2), were isolated along with C-1027 chromophore-III and fijiolides A and B (35) from a culture of an Arctic marine actinomycete Streptomyces strain. The chemical structures of 1 and 2 were elucidated through NMR, mass, UV, and IR spectroscopy. The hexose moieties in 1 were determined to be d-glucose from a combination of acid hydrolysis, derivatization, and gas chromatographic analyses. Arcticoside (1) and C-1027 chromophore-V (2), which have a benzoxazine ring, inhibited Candida albicans isocitrate lyase. Chromophore-V (2) exhibited significant cytotoxicity against breast carcinoma MDA-MB231 cells and colorectal carcinoma cells (line HCT-116), with IC50 values of 0.9 and 2.7 μM, respectively. Full article
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