Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

remove_circle_outline

Search Results (1)

Search Parameters:
Keywords = erythropenia

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
13 pages, 763 KiB  
Article
Processed Aloe vera Gel Ameliorates Cyclophosphamide-Induced Immunotoxicity
by Sun-A Im, Ki-Hyang Kim, Hee-Suk Kim, Ki-Hwa Lee, Eunju Shin, Seon-Gil Do, Tae Hyung Jo, Young In Park and Chong-Kil Lee
Int. J. Mol. Sci. 2014, 15(11), 19342-19354; https://doi.org/10.3390/ijms151119342 - 24 Oct 2014
Cited by 30 | Viewed by 7850
Abstract
The effects of processed Aloe vera gel (PAG) on cyclophosphamide (CP)-induced immunotoxicity were examined in mice. Intraperitoneal injection of CP significantly reduced the total number of lymphocytes and erythrocytes in the blood. Oral administration of PAG quickly restored CP-induced lymphopenia and erythropenia in [...] Read more.
The effects of processed Aloe vera gel (PAG) on cyclophosphamide (CP)-induced immunotoxicity were examined in mice. Intraperitoneal injection of CP significantly reduced the total number of lymphocytes and erythrocytes in the blood. Oral administration of PAG quickly restored CP-induced lymphopenia and erythropenia in a dose-dependent manner. The reversal of CP-induced hematotoxicity by PAG was mediated by the functional preservation of Peyer’s patch cells. Peyer’s patch cells isolated from CP-treated mice, which were administered PAG, produced higher levels of T helper 1 cytokines and colony-stimulating factors (CSF) in response to concanavalin A stimulation as compared with those isolated from CP-treated control mice. PAG-derived polysaccharides directly activated Peyer’s patch cells isolated from normal mice to produce cytokines including interleukin (IL)-6, IL-12, interferon-γ, granulocyte-CSF, and granulocyte-macrophage-CSF. The cytokines produced by polysaccharide-stimulated Peyer’s patch cells had potent proliferation-inducing activity on mouse bone marrow cells. In addition, oral administration of PAG restored IgA secretion in the intestine after CP treatment. These results indicated that PAG could be an effective immunomodulator and that it could prevent CP-induced immunotoxic side effects. Full article
(This article belongs to the Section Biochemistry)
Show Figures

Figure 1

Back to TopTop