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Keywords = dolastane

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32 pages, 1388 KiB  
Review
Natural Products and Derivatives as Potential Zika virus Inhibitors: A Comprehensive Review
by Rosângela Santos Pereira, Françoise Camila Pereira Santos, Priscilla Rodrigues Valadares Campana, Vivian Vasconcelos Costa, Rodrigo Maia de Pádua, Daniele G. Souza, Mauro Martins Teixeira and Fernão Castro Braga
Viruses 2023, 15(5), 1211; https://doi.org/10.3390/v15051211 - 20 May 2023
Cited by 20 | Viewed by 4919
Abstract
Zika virus (ZIKV) is an arbovirus whose infection in humans can lead to severe outcomes. This article reviews studies reporting the anti-ZIKV activity of natural products (NPs) and derivatives published from 1997 to 2022, which were carried out with NPs obtained from plants [...] Read more.
Zika virus (ZIKV) is an arbovirus whose infection in humans can lead to severe outcomes. This article reviews studies reporting the anti-ZIKV activity of natural products (NPs) and derivatives published from 1997 to 2022, which were carried out with NPs obtained from plants (82.4%) or semisynthetic/synthetic derivatives, fungi (3.1%), bacteria (7.6%), animals (1.2%) and marine organisms (1.9%) along with miscellaneous compounds (3.8%). Classes of NPs reported to present anti-ZIKV activity include polyphenols, triterpenes, alkaloids, and steroids, among others. The highest values of the selectivity index, the ratio between cytotoxicity and antiviral activity (SI = CC50/EC50), were reported for epigallocatechin gallate (SI ≥ 25,000) and anisomycin (SI ≥ 11,900) obtained from Streptomyces bacteria, dolastane (SI = 1246) isolated from the marine seaweed Canistrocarpus cervicorni, and the flavonol myricetin (SI ≥ 862). NPs mostly act at the stages of viral adsorption and internalization in addition to presenting virucidal effect. The data demonstrate the potential of NPs for developing new anti-ZIKV agents and highlight the lack of studies addressing their molecular mechanisms of action and pre-clinical studies of efficacy and safety in animal models. To the best of our knowledge, none of the active compounds has been submitted to clinical studies. Full article
(This article belongs to the Special Issue Recent Advances in Antiviral Natural Products)
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15 pages, 793 KiB  
Article
Brown Algae Padina sanctae-crucis Børgesen: A Potential Nutraceutical
by Raquel B. S. S. Nogueira, Anna Cláudia A. Tomaz, Déborah R. Pessoa, Aline L. Xavier, João Carlos L. R. Pita, Marianna V. Sobral, Marcela L. C. Pontes, Hilzeth L. F. Pessôa, Margareth F. F. M. Diniz, George Emmanuel C. Miranda, Maria Aparecida R. Vieira, Marcia O. M. Marques, Maria De Fátima V. Souza and Emídio V. L. Cunha
Mar. Drugs 2017, 15(10), 251; https://doi.org/10.3390/md15100251 - 26 Sep 2017
Cited by 7 | Viewed by 6893
Abstract
Padina sanctae-crucis Børgesen is distributed worldwide in tropical and subtropical seas; belongs to the Dictyotaceae family, and has proven to be an exceptional source of biologically active compounds. Four compounds were isolated and identified, namely: dolastane diterpene new for the genus Padina; [...] Read more.
Padina sanctae-crucis Børgesen is distributed worldwide in tropical and subtropical seas; belongs to the Dictyotaceae family, and has proven to be an exceptional source of biologically active compounds. Four compounds were isolated and identified, namely: dolastane diterpene new for the genus Padina; phaeophytin and hidroxy-phaeophytin new for the family Dictyotaceae, and; mannitol first described in this species. Saturated fatty acids as compared to the percentages of unsaturated fatty acids were shown to be present in greater abundance. Palmitic and linolenic acid were the main saturated and unsaturated acids, respectively. Cytotoxic and antioxidant activities were evaluated using human erythrocytes. In vivo evaluations of acute toxicity and genotoxicity were performed in mice. Methanolic extract of P. sanctae-crucis presented antioxidant activity and did not induce cytotoxicity, genotoxicity or acute toxicity. Since Padina sanctae-crucis is already used as food, has essential fatty acids for the nutrition of mammals, does not present toxicity and has antioxidant activity, it can be considered as a potential nutraceutical. Full article
(This article belongs to the Special Issue Nutraceuticals and Functional Foods)
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8 pages, 751 KiB  
Article
Two New Oxodolastane Diterpenes from the Jamaican Macroalga Canistrocarpus cervicornis
by Sanjay Campbell, JeAnn Murray, Rupika Delgoda and Winklet Gallimore
Mar. Drugs 2017, 15(6), 150; https://doi.org/10.3390/md15060150 - 30 May 2017
Cited by 7 | Viewed by 4999
Abstract
The chemical investigation of the organic extract of Canistrocarpus cervicornis, collected at Drunken Man’s Cay at Port Royal, Jamaica, has led to the isolation of two new dolastane diterpenes 4R-acetoxy-8S,9S-epoxy-14S-hydroxy-7-oxodolastane (1) and 4 [...] Read more.
The chemical investigation of the organic extract of Canistrocarpus cervicornis, collected at Drunken Man’s Cay at Port Royal, Jamaica, has led to the isolation of two new dolastane diterpenes 4R-acetoxy-8S,9S-epoxy-14S-hydroxy-7-oxodolastane (1) and 4R-hydroxy-8S,9S-epoxy-14S-hydroxy-7-oxodolastane (2) and the previously isolated dolastane (4R,9S,14S)-4,9,14-trihydroxydolast-1(15),7-diene (3) as a major diterpene constituent. The structures of the new compounds were elucidated by extensive spectroscopic analyses. Compounds 1–3 were evaluated for their cytotoxicity against human tumor cell lines PC3 and HT29. The results revealed that the dolastane diterpenes (1–3) displayed moderate, concentration dependent, cytotoxicity. Full article
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9 pages, 324 KiB  
Article
Isolation and Structure Elucidation of Three New Dolastanes from the Brown Alga Dilophus spiralis
by Efstathia Ioannou, Constantinos Vagias and Vassilios Roussis
Mar. Drugs 2013, 11(4), 1104-1112; https://doi.org/10.3390/md11041104 - 2 Apr 2013
Cited by 8 | Viewed by 5580
Abstract
Three new dolastane diterpenes (1–3) and five previously reported perhydroazulenes were isolated from the organic extracts of the brown alga Dilophus spiralis. The structure elucidation and the assignment of the relative configurations of the isolated natural products were [...] Read more.
Three new dolastane diterpenes (1–3) and five previously reported perhydroazulenes were isolated from the organic extracts of the brown alga Dilophus spiralis. The structure elucidation and the assignment of the relative configurations of the isolated natural products were based on extensive analyses of their spectroscopic data, whereas the absolute configuration of metabolite 2 was determined through its chemical conversion to a previously isolated compound of known configuration. Full article
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