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Keywords = digital hemoglobinometer

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12 pages, 1027 KB  
Article
Correction Equation for Hemoglobin Values Obtained Using Point of Care Tests—A Step towards Realistic Anemia Burden Estimates
by Gomathi Ramaswamy, Abhishek Jaiswal, Kashish Vohra, Ravneet Kaur, Mohan Bairwa, Archana Singh, Vani Sethi and Kapil Yadav
Diagnostics 2022, 12(12), 3191; https://doi.org/10.3390/diagnostics12123191 - 16 Dec 2022
Cited by 4 | Viewed by 3611
Abstract
Digital hemoglobinometers have been used as point-of-care tests (POCT) to estimate the burden of anemia in community-based studies and national-level surveys in India. As the accuracy of hemoglobin estimated in POCT varies, there is a need for adjustments to the POCT-hemoglobin to ensure [...] Read more.
Digital hemoglobinometers have been used as point-of-care tests (POCT) to estimate the burden of anemia in community-based studies and national-level surveys in India. As the accuracy of hemoglobin estimated in POCT varies, there is a need for adjustments to the POCT-hemoglobin to ensure they are closer to reality and are comparable. We used data (collected between 2016 and 2020) (N = 1145) from four studies from India: three among pregnant women and 6–59-month-old children from Haryana and the fourth from a national nutritional survey among 1–19-year-old children. We compared the same individuals’ POCT-hemoglobin (capillary blood) and automated hematology analyzers (AHA) hemoglobin (venous blood) and developed a predictive linear regression model to obtain the correction equation for POCT-hemoglobin. We analyzed paired data from 1145 participants. The correction equation for obtaining the true hemoglobin value = 3.35 + 0.71 × POCT-hemoglobin using capillary blood (adjusted R2—64.4% and mean squared error −0.841 g/dL). In comparison with the AHA-hemoglobin, the mean difference of POCT-hemoglobin was 0.2 g/dL, while with the predicted Hb obtained from the correction equation it was 0.01 g/dL. The correction equation was the first attempt at deriving the true hemoglobin values from the POCTs. There is a need for multi-country collaborative studies to improve the correction equation by adjusting for factors affecting hemoglobin estimation. Full article
(This article belongs to the Section Point-of-Care Diagnostics and Devices)
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