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Keywords = cryptoechinuline

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11 pages, 1034 KiB  
Article
Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus
by Olga F. Smetanina, Anton N. Yurchenko, Elena V. Girich (Ivanets), Phan Thi Hoai Trinh, Alexander S. Antonov, Sergey A. Dyshlovoy, Gunhild von Amsberg, Natalya Y. Kim, Ekaterina A. Chingizova, Evgeny A. Pislyagin, Ekaterina S. Menchinskaya, Ekaterina A. Yurchenko, Tran Thi Thanh Van and Shamil S. Afiyatullov
Molecules 2020, 25(1), 61; https://doi.org/10.3390/molecules25010061 - 23 Dec 2019
Cited by 18 | Viewed by 4829
Abstract
Seven known echinulin-related indolediketopiperazine alkaloids (17) were isolated from the Vietnamese sediment-derived fungus Aspergillus niveoglaucus. Using chiral HPLC, the enantiomers of cryptoechinuline B (1) were isolated as individual compounds for the first time. (+)-Cryptoechinuline B ( [...] Read more.
Seven known echinulin-related indolediketopiperazine alkaloids (17) were isolated from the Vietnamese sediment-derived fungus Aspergillus niveoglaucus. Using chiral HPLC, the enantiomers of cryptoechinuline B (1) were isolated as individual compounds for the first time. (+)-Cryptoechinuline B (1a) exhibited neuroprotective activity in 6-OHDA-, paraquat-, and rotenone-induced in vitro models of Parkinson’s disease. (−)-Cryptoechinuline B (1b) and neoechinulin C (5) protected the neuronal cells against paraquat-induced damage in a Parkinson’s disease model. Neoechinulin B (4) exhibited cytoprotective activity in a rotenone-induced model, and neoechinulin (7) showed activity in the 6-OHDA-induced model. Full article
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