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Keywords = cell jamming state transition

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20 pages, 1621 KB  
Review
Entropy Production in Epithelial Monolayers Due to Collective Cell Migration
by Ivana Pajic-Lijakovic and Milan Milivojevic
Entropy 2025, 27(5), 483; https://doi.org/10.3390/e27050483 - 29 Apr 2025
Viewed by 720
Abstract
The intricate multi-scale phenomenon of entropy generation, resulting from the inhomogeneous and anisotropic rearrangement of cells during their collective migration, is examined across three distinct regimes: (i) convective, (ii) conductive (diffusion), and (iii) sub-diffusion. The collective movement of epithelial monolayers on substrate matrices [...] Read more.
The intricate multi-scale phenomenon of entropy generation, resulting from the inhomogeneous and anisotropic rearrangement of cells during their collective migration, is examined across three distinct regimes: (i) convective, (ii) conductive (diffusion), and (iii) sub-diffusion. The collective movement of epithelial monolayers on substrate matrices induces the accumulation of mechanical stress within the cells, which subsequently influences cell packing density, velocity, and alignment. Variations in these physical parameters affect cell-cell interactions, which play a crucial role in the storage and dissipation of energy within multicellular systems. The internal dynamics of entropy generation, as a consequence of energy dissipation, are characterized in each regime using viscoelastic constitutive models and the surface properties at the cell-matrix biointerface. The focus of this theoretical review is to clarify how cells can modulate their rate of energy dissipation by altering cell-cell and cell-matrix adhesion interactions, undergoing changes in shape, and re-establishing polarity due to the contact inhibition of locomotion. We approach these questions by discussing the physical aspects of these complex phenomena. Full article
(This article belongs to the Special Issue From Order to Disorder: Superfluidity, Stochastic Processes, and the Dynamics of Life—Dedicated to Professor Peter McClintock on the Occasion of His 85th Birthday)
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23 pages, 5221 KB  
Article
Jamming Transitions in Astrocytes and Glioblastoma Are Induced by Cell Density and Tension
by Urszula Hohmann, Julian Cardinal von Widdern, Chalid Ghadban, Maria Cristina Lo Giudice, Grégoire Lemahieu, Elisabetta Ada Cavalcanti-Adam, Faramarz Dehghani and Tim Hohmann
Cells 2023, 12(1), 29; https://doi.org/10.3390/cells12010029 - 21 Dec 2022
Cited by 5 | Viewed by 2818
Abstract
Collective behavior of cells emerges from coordination of cell–cell-interactions and is important to wound healing, embryonic and tumor development. Depending on cell density and cell–cell interactions, a transition from a migratory, fluid-like unjammed state to a more static and solid-like jammed state or [...] Read more.
Collective behavior of cells emerges from coordination of cell–cell-interactions and is important to wound healing, embryonic and tumor development. Depending on cell density and cell–cell interactions, a transition from a migratory, fluid-like unjammed state to a more static and solid-like jammed state or vice versa can occur. Here, we analyze collective migration dynamics of astrocytes and glioblastoma cells using live cell imaging. Furthermore, atomic force microscopy, traction force microscopy and spheroid generation assays were used to study cell adhesion, traction and mechanics. Perturbations of traction and adhesion were induced via ROCK or myosin II inhibition. Whereas astrocytes resided within a non-migratory, jammed state, glioblastoma were migratory and unjammed. Furthermore, we demonstrated that a switch from an unjammed to a jammed state was induced upon alteration of the equilibrium between cell–cell-adhesion and tension from adhesion to tension dominated, via inhibition of ROCK or myosin II. Such behavior has implications for understanding the infiltration of the brain by glioblastoma cells and may help to identify new strategies to develop anti-migratory drugs and strategies for glioblastoma-treatment. Full article
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