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Keywords = carboacylation

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16 pages, 3205 KiB  
Article
Nickel-Catalyzed Three-Component 1,2-Carboacylation of Alkenes
by Shengzhou Jin, Lanfen Wang, Yinggang Jia, Wenbo Ma and Dingyi Wang
Molecules 2024, 29(18), 4295; https://doi.org/10.3390/molecules29184295 - 10 Sep 2024
Cited by 1 | Viewed by 1517
Abstract
Ketones, prevalent in many biologically significant molecules, require the development of novel methods to synthesize these structures, which is a critical endeavor in organic synthesis. Transition metal catalysis has proven to be an effective method for synthesizing ketones. However, the scope of these [...] Read more.
Ketones, prevalent in many biologically significant molecules, require the development of novel methods to synthesize these structures, which is a critical endeavor in organic synthesis. Transition metal catalysis has proven to be an effective method for synthesizing ketones. However, the scope of these substrates remains relatively limited, particularly due to their incompatibility with sensitive functional groups. Herein, we report a Ni-catalyzed three-component 1,2-carboacylation of alkenes, which activates secondary/tertiary alkyl bromides. This method offers significant advantages: simplicity of operation, ready availability of substrates, and broad substrate applicability. A series of experimental studies have helped clarify the key mechanistic pathways involved in this cascade reaction. Full article
(This article belongs to the Special Issue Recent Advances in Transition Metal Catalysis)
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