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Keywords = calcarides A–E

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15 pages, 590 KiB  
Article
Calcarides A–E, Antibacterial Macrocyclic and Linear Polyesters from a Calcarisporium Strain
by Johanna Silber, Birgit Ohlendorf, Antje Labes, Arlette Erhard and Johannes F. Imhoff
Mar. Drugs 2013, 11(9), 3309-3323; https://doi.org/10.3390/md11093309 - 29 Aug 2013
Cited by 46 | Viewed by 7791
Abstract
Bioactive compounds were detected in crude extracts of the fungus, Calcarisporium sp. KF525, which was isolated from German Wadden Sea water samples. Purification of the metabolites from the extracts yielded the five known polyesters, 15G256α, α-2, β, β-2 and π (1 [...] Read more.
Bioactive compounds were detected in crude extracts of the fungus, Calcarisporium sp. KF525, which was isolated from German Wadden Sea water samples. Purification of the metabolites from the extracts yielded the five known polyesters, 15G256α, α-2, β, β-2 and π (15), and five new derivatives thereof, named calcarides A–E (610). The chemical structures of the isolated compounds were elucidated on the basis of one- and two-dimensional NMR spectroscopy supported by UV and HRESIMS data. The compounds exhibited inhibitory activities against Staphylococcus epidermidis, Xanthomonas campestris and Propionibacterium acnes. As the antibacterial activities were highly specific with regard to compound and test strain, a tight structure-activity relationship is assumed. Full article
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