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Keywords = briarenones

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Article
Briarenones A‒C, New Briarellin Diterpenoids from the Gorgonian Briareum violaceum
by Yang Cheng, Atallah F. Ahmed, Raha S. Orfali, Chang-Feng Dai and Jyh-Horng Sheu
Mar. Drugs 2019, 17(2), 120; https://doi.org/10.3390/md17020120 - 17 Feb 2019
Cited by 7 | Viewed by 3936
Abstract
Three new eunicellin-derived diterpenoids of briarellin type, briarenones A‒C (13), were isolated from a Formosan gorgonian Briareum violaceum. The chemical structures of the compounds were elucidated on the basis of extensive spectroscopic analyses, including two-dimensional (2D) NMR. The [...] Read more.
Three new eunicellin-derived diterpenoids of briarellin type, briarenones A‒C (13), were isolated from a Formosan gorgonian Briareum violaceum. The chemical structures of the compounds were elucidated on the basis of extensive spectroscopic analyses, including two-dimensional (2D) NMR. The absolute configuration of 1 was further confirmed by a single crystal X-ray diffraction analysis. The in vitro cytotoxic and anti-inflammatory potentialities of the isolated metabolites were tested against the growth of a limited panel of cancer cell lines and against the production of superoxide anions and elastase release in N-formyl-methionyl-leucyl-phenyl-alanine and cytochalasin B (fMLF/CB)-stimulated human neutrophils, respectively. Full article
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