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Keywords = benzylamino-methanones

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13 pages, 331 KiB  
Article
Design, Synthesis, and Biological Evaluation of Benzylamino-Methanone Based Cholesteryl Ester Transfer Protein Inhibitors
by Ghassan Abu Sheikha, Reema Abu Khalaf, Areej Melhem and Ghadeer Albadawi
Molecules 2010, 15(8), 5721-5733; https://doi.org/10.3390/molecules15085721 - 19 Aug 2010
Cited by 24 | Viewed by 10198
Abstract
Cholesteryl ester transfer protein (CETP) is a glycoprotein involved in transporting lipoprotein particles and neutral lipids between high-density lipoprotein (HDL) and low density lipoproteins (LDL) and therefore its a proper target for treating dyslipidemia and related disorders. Guided by our previosuly-reported pharmacophore and [...] Read more.
Cholesteryl ester transfer protein (CETP) is a glycoprotein involved in transporting lipoprotein particles and neutral lipids between high-density lipoprotein (HDL) and low density lipoproteins (LDL) and therefore its a proper target for treating dyslipidemia and related disorders. Guided by our previosuly-reported pharmacophore and QSAR models for CETP inhibition, we synthesized and bioassayed a series of benzylamino-methanones. The most potent illustrated 30% CETP inhibition at 10 μM. Full article
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