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Keywords = benzyl alkyl imidazolium ionic liquids

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18 pages, 2453 KiB  
Article
New Ionic Liquid Microemulsion-Mediated Synthesis of Silver Nanoparticles for Skin Bacterial Infection Treatments
by Fayez Althobaiti, Ola A. Abu Ali, Islam Kamal, Mohammad Y. Alfaifi, Ali A. Shati, Eman Fayad, Serag Eldin I. Elbehairi, Reda F. M. Elshaarawy and W. Abd El-Fattah
Antibiotics 2023, 12(2), 247; https://doi.org/10.3390/antibiotics12020247 - 25 Jan 2023
Cited by 11 | Viewed by 2352
Abstract
This work reports a new approach for the synthesis of extremely small monodispersed silver nanoparticles (AgNPs) (2.9–1.5) by reduction of silver nitrate in a new series of benzyl alkyl imidazolium ionic liquids (BAIILs)-based microemulsions (3a–f) as media and stabilizing agents. Interestingly, AgNPs isolated [...] Read more.
This work reports a new approach for the synthesis of extremely small monodispersed silver nanoparticles (AgNPs) (2.9–1.5) by reduction of silver nitrate in a new series of benzyl alkyl imidazolium ionic liquids (BAIILs)-based microemulsions (3a–f) as media and stabilizing agents. Interestingly, AgNPs isolated from the IILMEs bearing the bulkiest substituents (tert-butyl and n-butyl) (3f) displayed almost no nanoparticle agglomeration. In an in vitro antibacterial test against ESKAPE pathogens, all AgNPs-BAIILs had potent antibiotic activity, as reflected by antibacterial efficiency indices. Furthermore, when compared to other nanoparticles, these were the most effective in preventing biofilm formation by the tested bacterial strains. Moreover, the MTT assay was used to determine the cytotoxicity of novel AgNPs-BAIILs on healthy human skin fibroblast (HSF) cell lines. The MTT assay revealed that novel AgNPs-BAIILs showed no significant toxic effects on the healthy cells. Thus, the novel AgNPs-BAIILs microemulsions could be used as safe antibiotics for skin bacterial infection treatments. AgNPs isolated from BAIIL (3c) was found to be the most effective antibiotic of the nanoparticles examined. Full article
(This article belongs to the Special Issue Molecular Methods in Antibiotics Discovery)
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14 pages, 1902 KiB  
Article
Novel Aryl-Imidazolium Ionic Liquids with Dual Brønsted/Lewis Acidity as Both Solvents and Catalysts for Friedel–Crafts Alkylation
by Che-Hsuan Yang, Jui-Cheng Chang, Tzi-Yi Wu, I-Wen Sun, Jun-Hao Wu and Wen-Yueh Ho
Appl. Sci. 2019, 9(22), 4743; https://doi.org/10.3390/app9224743 - 7 Nov 2019
Cited by 11 | Viewed by 3603
Abstract
Unique tunable aryl-imidazolium magnetic ionic liquids with dual functions as a solvent–catalyst and dual Brønsted–Lewis acidity (B-L MILs) are applied for Friedel–Crafts alkylation without additional solvents. The catalytic properties of these B-L MILs in the Friedel–Crafts alkylation of p-xylene with benzyl chloride are [...] Read more.
Unique tunable aryl-imidazolium magnetic ionic liquids with dual functions as a solvent–catalyst and dual Brønsted–Lewis acidity (B-L MILs) are applied for Friedel–Crafts alkylation without additional solvents. The catalytic properties of these B-L MILs in the Friedel–Crafts alkylation of p-xylene with benzyl chloride are investigated. The various reaction parameters, including the catalyst dosage, reaction time, reaction temperature, molar ratio of reactants, and reusability, are discussed. The results show that the B-L MIL 5c has more excellent product selectivity (>99%) and reactant conversion (>99%) under the following optimum conditions (reaction temperature = 80 °C, reaction time = 0.5 h, molar ratio of p-xylene to benzyl chloride = 6:1, and catalyst 5c dosage = 1.0 mole %) than traditional catalysts reported in the previous literature. Specifically, due to the mesomeric effect between the FeCl4 anion and hydrogen atom at cationic moiety, the catalyst B-L MILs with the molar fraction of FeCl3 equal to 0.5 can be easily recovered and provide satisfactory catalytic activity after being re-used six times. Full article
(This article belongs to the Special Issue Ionic Liquids in Green Chemistry)
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