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Keywords = arylthio/cyclohexylthio-lapachones

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12 pages, 1817 KB  
Article
Efficient Catalytic Oxidation of 3-Arylthio- and 3-Cyclohexylthio-lapachone Derivatives to New Sulfonyl Derivatives and Evaluation of Their Antibacterial Activities
by Mariana F. do C. Cardoso, Ana T. P. C. Gomes, Caroline Dos S. Moreira, Mário M. Q. Simões, Maria G. P. M. S. Neves, David R. Da Rocha, Fernando De C. Da Silva, Catarina Moreirinha, Adelaide Almeida, Vitor F. Ferreira and José A. S. Cavaleiro
Molecules 2017, 22(2), 302; https://doi.org/10.3390/molecules22020302 - 16 Feb 2017
Cited by 10 | Viewed by 5916
Abstract
New sulfonyl-lapachones were efficiently obtained through the catalytic oxidation of arylthio- and cyclohexylthio-lapachone derivatives with hydrogen peroxide in the presence of a Mn(III) porphyrin complex. The antibacterial activities of the non-oxidized and oxidized lapachone derivatives against the Gram-negative bacteria Escherichia coli and the [...] Read more.
New sulfonyl-lapachones were efficiently obtained through the catalytic oxidation of arylthio- and cyclohexylthio-lapachone derivatives with hydrogen peroxide in the presence of a Mn(III) porphyrin complex. The antibacterial activities of the non-oxidized and oxidized lapachone derivatives against the Gram-negative bacteria Escherichia coli and the Gram-positive bacteria Staphylococcus aureus were evaluated after their incorporation into polyvinylpyrrolidone (PVP) micelles. The obtained results show that the PVP-formulations of the lapachones 4bg and of the sulfonyl-lapachones 7e and 7g reduced the growth of S. aureus. Full article
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