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Keywords = arylidenetetramic acid

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13 pages, 481 KiB  
Article
Ruthenium-Catalyzed Selective Hydrogenation of bis-Arylidene Tetramic Acids. Application to the Synthesis of Novel Structurally Diverse Pyrrolidine-2,4-diones
by Christos S. Karaiskos, Dimitris Matiadis, John Markopoulos and Olga Igglessi-Markopoulou
Molecules 2011, 16(7), 6116-6128; https://doi.org/10.3390/molecules16076116 - 20 Jul 2011
Cited by 3 | Viewed by 6040
Abstract
Catalytic hydrogenation of 3,5-bis-arylidenetetramic acids, known for their biological activity, has been developed. The chemoselective ruthenium-catalyzed reduction of the exocyclic carbon-carbon double bonds on pyrrolidine-2,4-dione ring system, containing other reducible functions, has been investigated. Depending on the substrate the yield of the hydrogenation [...] Read more.
Catalytic hydrogenation of 3,5-bis-arylidenetetramic acids, known for their biological activity, has been developed. The chemoselective ruthenium-catalyzed reduction of the exocyclic carbon-carbon double bonds on pyrrolidine-2,4-dione ring system, containing other reducible functions, has been investigated. Depending on the substrate the yield of the hydrogenation process can reach up to 95%. The structural elucidation has been established using NMR and HRMS spectral data. Full article
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