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Keywords = antihypothyroid effect

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15 pages, 2144 KiB  
Article
Antihypothyroid Effect of Salidroside
by Nazym K. Korbozova, Nataliya O. Kudrina, Nataliya A. Zhukova, Alexander E. Grazhdannikov, Irina V. Blavachinskaya, Gulnaz A. Seitimova, Timur E. Kulmanov, Tatyana G. Tolstikova and Nina V. Terletskaya
Molecules 2022, 27(21), 7487; https://doi.org/10.3390/molecules27217487 - 2 Nov 2022
Cited by 7 | Viewed by 2562
Abstract
In terms of prevalence, thyroid pathology, associated both with a violation of the gland function and changes in its structure, occupies one of the main places in clinical endocrinology. The problem of developing low-toxic and highly effective herbal preparations for the correction of [...] Read more.
In terms of prevalence, thyroid pathology, associated both with a violation of the gland function and changes in its structure, occupies one of the main places in clinical endocrinology. The problem of developing low-toxic and highly effective herbal preparations for the correction of thyroid hypofunction and its complications is urgent. Salidroside is a glucoside of tyrosol, found mostly in the roots of Rhodiola spp., and has various positive biological activities. The purpose of this study was to study the antihypothyroid potential of salidrosid-containing extract from R. semenovii roots, which was evaluated on a mercazolyl hypothyroidism model. We showed that extract containing salidroside is a safe and effective means of hypothyroidism correction, significantly reducing (p ≤ 0.001) the level of thyroid-stimulating hormone and increasing the level of thyroid hormones. The combined use of R. semenovii extract with potassium iodide enhances the therapeutic effect of the extract by 1.3-times. Full article
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