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Keywords = anti-LOXL2 monoclonal Ab

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25 pages, 8632 KB  
Systematic Review
Wound Modulations in Glaucoma Surgery: A Systematic Review
by Bhoomi Dave, Monica Patel, Sruthi Suresh, Mahija Ginjupalli, Arvind Surya, Mohannad Albdour and Karanjit S. Kooner
Bioengineering 2024, 11(5), 446; https://doi.org/10.3390/bioengineering11050446 - 30 Apr 2024
Cited by 10 | Viewed by 6375
Abstract
Excessive fibrosis and resultant poor control of intraocular pressure (IOP) reduce the efficacy of glaucoma surgeries. Historically, corticosteroids and anti-fibrotic agents, such as mitomycin C (MMC) and 5-fluorouracil (5-FU), have been used to mitigate post-surgical fibrosis, but these have unpredictable outcomes. Therefore, there [...] Read more.
Excessive fibrosis and resultant poor control of intraocular pressure (IOP) reduce the efficacy of glaucoma surgeries. Historically, corticosteroids and anti-fibrotic agents, such as mitomycin C (MMC) and 5-fluorouracil (5-FU), have been used to mitigate post-surgical fibrosis, but these have unpredictable outcomes. Therefore, there is a need to develop novel treatments which provide increased effectiveness and specificity. This review aims to provide insight into the pathophysiology behind wound healing in glaucoma surgery, as well as the current and promising future wound healing agents that are less toxic and may provide better IOP control. Full article
(This article belongs to the Special Issue Meeting Challenges in the Diagnosis and Treatment of Glaucoma)
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