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Keywords = aminoflavonoid

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22 pages, 9770 KiB  
Review
Therapeutic Perspectives of Aminoflavonoids—A Review
by Monika Stompor-Gorący, Agata Bajek-Bil, Natalia Potocka and Izabela Zawlik
Int. J. Mol. Sci. 2025, 26(5), 2014; https://doi.org/10.3390/ijms26052014 - 25 Feb 2025
Cited by 1 | Viewed by 1031
Abstract
Natural compounds containing nitrogen are a source of many biologically active molecules used as drugs. Due to their multidirectional effects, they represent effective therapeutic compounds in many medical areas. Flavonoids, as well as their bioprecursors, chalcones, that occur in plants possess a number [...] Read more.
Natural compounds containing nitrogen are a source of many biologically active molecules used as drugs. Due to their multidirectional effects, they represent effective therapeutic compounds in many medical areas. Flavonoids, as well as their bioprecursors, chalcones, that occur in plants possess a number of medicinal benefits. Their synthetic amino derivatives constitute a large group of compounds that exhibit pharmacological activity. Due to the increasing level of drug resistance among patients, new therapeutic agents and options are urgently needed. Therefore, aminoflavonoids may be a promising source of new drugs. In this review, the biological activities of flavonoids, including chalcones, with complexes containing a nitrogen atom and the aminoflavones Ru and Pt are summarized. The purpose of this review is to provide an overview of the synthesis and pharmacological activity of aminoflavonoids and to show how synthetic modifications of these compounds can influence their biological activities. It covers the most recent reports on obtaining aminoflavones, aminochalcones, and their derivatives, along with information about their anticancer, antimicrobial, antimalarial, antiviral, and anti-inflammatory activities. Full article
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14 pages, 1713 KiB  
Article
Synthesis and In Vitro Anticancer Evaluation of Novel Chrysin and 7-Aminochrysin Derivatives
by Szabolcs Mayer, Péter Keglevich, Péter Ábrányi-Balogh, Áron Szigetvári, Miklós Dékány, Csaba Szántay and László Hazai
Molecules 2020, 25(4), 888; https://doi.org/10.3390/molecules25040888 - 17 Feb 2020
Cited by 23 | Viewed by 5075
Abstract
Chrysin is a naturally occurring flavonoid with mild anticancer activity. In this paper we report the synthesis of new chrysin derivatives alkylated with N-phenylchloroacetamides in position 7. A novel method was developed for the preparation of 7-aminochrysin derivatives via the Smiles rearrangement, [...] Read more.
Chrysin is a naturally occurring flavonoid with mild anticancer activity. In this paper we report the synthesis of new chrysin derivatives alkylated with N-phenylchloroacetamides in position 7. A novel method was developed for the preparation of 7-aminochrysin derivatives via the Smiles rearrangement, resulting in diphenylamine-type compounds. In silico studies of the Smiles rearrangement were performed. We also present the in vitro antiproliferative activity of the synthesized compounds against 60 human tumor cell lines (NCI60). The most potent derivative exhibited nanomolar antitumor activity on the MCF7 cell line of breast cancer (GI50 = 30 nM) and on the HCT-15 cell line of colon cancer (GI50 = 60 nM). Full article
(This article belongs to the Collection Natural Products: Anticancer Potential and Beyond)
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