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Keywords = alkylarenes

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43 pages, 10073 KiB  
Review
Benzylic C–H Oxidation: Recent Advances and Applications in Heterocyclic Synthesis
by Nonhlelo Majola and Vineet Jeena
Molecules 2024, 29(24), 6047; https://doi.org/10.3390/molecules29246047 - 22 Dec 2024
Viewed by 2742
Abstract
Benzylic C–H oxidation to form carbonyl compounds, such as ketones, is a fundamental transformation in organic synthesis as it allows for the preparation of versatile intermediates. In this review, we highlight the synthesis of aromatic ketones via catalytic, electrochemical, and photochemical oxidation of [...] Read more.
Benzylic C–H oxidation to form carbonyl compounds, such as ketones, is a fundamental transformation in organic synthesis as it allows for the preparation of versatile intermediates. In this review, we highlight the synthesis of aromatic ketones via catalytic, electrochemical, and photochemical oxidation of alkylarenes using different catalysts and oxidants in the past 5 years. Additionally, we also discuss the synthesis of heterocyclic molecules using benzylic C–H oxidation as a key step. These methods can potentially be used in medicinal, synthetic, and inorganic chemistry. Full article
(This article belongs to the Special Issue Recent Advances in C–H Functionalization)
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