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17 pages, 807 KB  
Review
The Potential Regulators of Amyloidogenic Pathway of APP Processing in Alzheimer’s Disease
by Daria Krawczuk, Agnieszka Kulczyńska-Przybik and Barbara Mroczko
Biomedicines 2025, 13(7), 1513; https://doi.org/10.3390/biomedicines13071513 - 20 Jun 2025
Cited by 3 | Viewed by 3399
Abstract
The amyloidogenic processing of amyloid precursor protein (APP) plays a pivotal role in the pathogenesis of Alzheimer’s disease (AD), primarily through the generation of amyloid-beta (Aβ) peptides, which aggregate to form toxic plaques in the brain. The regulation of amyloidogenic APP processing is [...] Read more.
The amyloidogenic processing of amyloid precursor protein (APP) plays a pivotal role in the pathogenesis of Alzheimer’s disease (AD), primarily through the generation of amyloid-beta (Aβ) peptides, which aggregate to form toxic plaques in the brain. The regulation of amyloidogenic APP processing is a complex interplay of enzymes, proteins, and signaling pathways, all of which contribute to the development and progression of Alzheimer’s disease. Understanding the intricate mechanisms and molecular players involved in APP processing substantially enhances our knowledge of Alzheimer’s disease pathology and holds promise for the development of biomarkers of ongoing pathology at the earliest stages of Alzheimer’s disease. In this review, we aimed to investigate selected factors that regulate the amyloidogenic pathway of APP processing. Full article
(This article belongs to the Section Neurobiology and Clinical Neuroscience)
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