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Keywords = adoptive cellular therapy limb salvage therapy

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13 pages, 288 KiB  
Review
Osteosarcoma: Current Concepts and Evolutions in Management Principles
by Pampina Pilavaki, Amir Gahanbani Ardakani, Panagiotis Gikas and Anastasia Constantinidou
J. Clin. Med. 2023, 12(8), 2785; https://doi.org/10.3390/jcm12082785 - 9 Apr 2023
Cited by 44 | Viewed by 7624
Abstract
Osteosarcoma is a rare malignancy arising from mesenchymal tissue, and represents the most common bone sarcoma. The management of osteosarcoma is challenging, and requires a multidisciplinary approach. In daily clinical practice, surgery, radiotherapy, and conventional chemotherapy constitute the therapeutic armamentarium against the disease. [...] Read more.
Osteosarcoma is a rare malignancy arising from mesenchymal tissue, and represents the most common bone sarcoma. The management of osteosarcoma is challenging, and requires a multidisciplinary approach. In daily clinical practice, surgery, radiotherapy, and conventional chemotherapy constitute the therapeutic armamentarium against the disease. However, a significant number of patients with initially localized osteosarcoma will experience local or distant recurrence, and the prognosis for metastatic disease remains dismal. There is a pressing need to identify novel therapeutic strategies to better manage osteosarcoma and improve survival outcomes. In this study, we present recent advances in the therapeutic management of osteosarcoma, including surgical and medical advances. The role of immunotherapy (immune checkpoint inhibitors, adoptive cellular therapy, cancer vaccines) and other targeted therapies including tyrosine kinase inhibitors is discussed; however, additional studies are required to delineate their roles in clinical practice. Full article
(This article belongs to the Section Oncology)
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