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The safe and efficient extraction of ore bodies under buildings contributes to the continued exploitation and utilization of mineral resources. To effectively reduce the mining-induced disturbance caused to surface buildings, the Vertical Crater Retreat (VCR) delayed backfilling method was applied at the Wuji iron mine according to mining theory and engineering experience, and the surface deformation under buildings was investigated through numerical simulation and on-site monitoring. The results show that stress concentration occurs at the top of the ore body and in surrounding rocks between ore veins, and the direction of the principal stress coincides with that of the main bearing capacity of the rock mass. With the increasing distance between the surrounding rock and the ore body, the stress disturbance in the surrounding rock attenuates gradually. The surface subsidence and deformation caused by ore mining exhibits the same northwest trend as the strike of the ore body, and the surface deformation in the X direction is greater than that in the Y direction. The surface deformation of the mining area near the 1# air shaft, Wuji village, steam autoclave workshop of the brick factory, and 1# substation is relatively large, while the surface subsidence, horizontal deformation, inclination, and curvature are all smaller than the critical values allowed for buildings and structures. This research provides a theoretical basis and engineering guidance for the prevention and control of surface deformation during mining under buildings and structures. Full article