Search Results (6)

MXenes, a family of two-dimensional carbide and nitride nanomaterials, have demonstrated significant promise across various technological domains, particularly in energy storage applications. This review critically examines scalable synthesis techniques for MXenes and their potential integration into next-generation rechargeable battery systems. We highlight both top-down and emerging bottom-up approaches, exploring their respective efficiencies, environmental impacts, and industrial feasibility. The paper further discusses the electrochemical behavior of MXenes in lithium-ion, sodium-ion, and aluminum-ion batteries, as well as their multifunctional roles in solid-state batteries—including as electrodes, additives, and solid electrolytes. Special emphasis is placed on surface functionalization, interlayer engineering, and ion transport properties. We also compare MXenes with conventional graphite anodes, analyzing their gravimetric and volumetric performance potential. Finally, challenges such as diffusion kinetics, power density limitations, and scalability are addressed, providing a comprehensive outlook on the future of MXenes in sustainable energy storage technologies. Full article

We argue here that in many ways, Ewing sarcoma (EwS) is a unique tumor entity and yet, it shares many commonalities with other immunologically cold solid malignancies. From the historical perspective, EwS, osteosarcoma (OS) and other bone and soft-tissue sarcomas were the first types of tumors treated with the immunotherapy approach: more than 100 years ago American surgeon William B. Coley injected his patients with a mixture of heat-inactivated bacteria, achieving survival rates apparently higher than with surgery alone. In contrast to OS which exhibits recurrent somatic copy-number alterations, EwS possesses one of the lowest mutation rates among cancers, being driven by a single oncogenic fusion protein, most frequently EWS-FLI1. In spite these differences, both EwS and OS are allied with immune tolerance and low immunogenicity. We discuss here the potential mechanisms of immune escape in these tumors, including low representation of tumor-specific antigens, low expression levels of MHC-I antigen-presenting molecules, accumulation of immunosuppressive M2 macrophages and myeloid proinflammatory cells, and release of extracellular vesicles (EVs) which are capable of reprogramming host cells in the tumor microenvironment and systemic circulation. We also discuss the vulnerabilities of EwS and OS and potential novel strategies for their targeting. Full article

Strategies for meeting Sustainable Development Goal 7 of providing access to electricity for all recognize the important role that off-grid solutions will need to play. Mini-grids will from part of this response, yet little data exists on household demand from these customers. Predicting demand accurately is a crucial part of planning financially viable mini-grid systems, so it is important to understand demand as fully as possible. This paper draws on metered data from two solar PV diesel hybrid mini-grid sites in Tanzania. It presents an analysis of load profiles from the different sites and categorizes households by demand characteristics. The paper then combines load profile data with household demographic and electrical asset ownership data to explore factors behind distinct load profile patterns of use. It concludes that load profiles are determined by a complex mix of appliance ownership, occupancy, and socio-economic status. Full article

Globally, 2.8 billion people still cook with biomass, resulting in health, environmental, and social challenges; electric cooking is a key option for a transition to modern energy cooking services. However, electric cooking is assumed to be too expensive, grids can be unreliable and the connection capacity of mini-grids and solar home systems is widely assumed to be insufficient. Developments in higher performance and lower cost batteries and solar photovoltaics can help, but they raise questions of affordability and environmental impacts. The range of issues is wide, and existing studies do not capture them coherently. A new suite of models is outlined that represents the technical, economic, human, and environmental benefits and impacts of delivering electric cooking services, with a life-cycle perspective. This paper represents the first time this diverse range of approaches has been brought together. The paper illustrates their use through combined application to case studies for transitions of households from traditional fuels to electric cooking: for urban grid-connected households in Zambia; for mini-grid connected households in Tanzania; and for off-grid households in Kenya. The results show that electric cooking can be cost-effective, and they demonstrate overall reductions in human and ecological impacts but point out potential impact ‘hotspots’. The network analysis shows that electric cooking can be accommodated to a significant extent on existing grids, due partly to diversity effects in the nature and timing of cooking practices. Full article

The ability of the immune system to precisely target and eliminate aberrant or infected cells has long been studied in the field of infectious diseases. Attempts to define and exploit these potent immunological processes in the fight against cancer has been a longstanding effort dating back over 100 years to when Dr. William Coley purposefully infected cancer patients with a cocktail of heat-killed bacteria to stimulate anti-cancer immune processes. Although the field of cancer immunotherapy has been dotted with skepticism at times, the success of immune checkpoint inhibitors and recent FDA approvals of autologous cell therapies have pivoted immunotherapy to center stage as one of the most promising strategies to treat cancer. This review aims to summarize historic milestones throughout the field of cancer immunotherapy as well as highlight current and promising immunotherapies in development. Full article