Search Results (7)

Background: Secondary immunodeficiency disease (SID) is a complex, heterogeneous condition that occurs when extrinsic factors weaken the immune system. Expert consensus guidelines recommend immunoglobulin replacement therapy to manage immunoglobulin G (IgG) levels and mitigate severe, recurrent, and persistent infections. Hyaluronidase-facilitated subcutaneous immunoglobulin (fSCIG) 10% is a dual-vial unit of IgG and recombinant human hyaluronidase; the latter enables absorption of higher volumes of IgG than conventional subcutaneous therapies. Methods: For this systematic literature review, Embase, MEDLINE^®, and the Cochrane Library were searched on 9 August 2023, with supplemental congress searches. Results: Eight studies fulfilled the inclusion criteria, reporting real-world evidence of the clinical effectiveness, safety, and tolerability of fSCIG 10% in 183 patients with SID in Europe from September 2014 to August 2021. The potential causes of SID were primarily hematological malignancies, most commonly chronic lymphocytic leukemia. Treatment was typically administered at 4-week or 3-week intervals, with doses of approximately 0.4 g/kg/month. Infections were rare during follow-up, with numerical reductions observed after fSCIG 10% treatment initiation compared with the period before initiation. Adverse reactions, including local infusion site reactions, and tolerability events were uncommon. Conclusions: Given the recency of fSCIG 10% use in patients with SID, there are opportunities for future research to better understand survival and patient-reported outcomes after receiving this treatment. Despite SID heterogeneity, this study demonstrates the feasibility of fSCIG 10% treatment for this condition. Full article

This essay places the Washington Library of Congress Heb. Ms 183, a Hebrew Qur’an translation from eighteenth-century Cochin, in its South Indian context. After pointing out important general differences between early modern European and South Asian inter-religious cultures and attitudes to translation, this essay analyzes three salient differences between Ms 183 and its Dutch source. Then, the essay scrutinizes three relevant and interrelated contexts: the eighteenth-century Indian diplomatic culture of owning and exchanging scriptural translations; the social position of Muslims and Jews as ‘guests’ and diplomatic brokers; and the rise of Muslim military power in Malabar. On this basis, I argue that this Hebrew Qur’an translation was intended to be cultural–diplomatic capital for Jewish diplomats dealing with Muslim rulers, indicating that not only rulers translated the scriptures of their subjects but also subjects those of their rulers. In addition, by showing how the Mysorean rulers implemented Islamic reforms and how Jewish practices were attuned to majoritarian religious practices, the essay suggests that Ms 183 was also meant to serve Jewish religious purposes, making this manuscript possibly a rare instance of using non-Jewish religious scriptures for Jewish religious practice. Full article

Background: Telemedicine is an effective, widely used strategy in the field of cystic fibrosis management. The objective of this scoping review is to summarize and analyze the scientific literature with the special focus on the tools and the strategies used in patients with a chronic disease, such as cystic fibrosis. Methods: This scoping review will be performed in accordance with the Joanna Briggs Institute methodology. In this context, the planned scoping review is a research synthesis that will map the literature on the applications of telemedicine and telemonitoring to the management of cystic fibrosis, with the aim to identify key concepts in the research and work to be conducted that may impact clinical practice. Studies will be included if they meet the following population, concept, and context criteria: all patients with cystic fibrosis receiving treatment with the tools of telemedicine and telemonitoring. No study design, publication type, or data restrictions will be applied. MEDLINE, Scopus, CINHAL, Pedro, Embase, Web of Science, ACM Digital Library, Health Technology Assessment Database (HTA), and Cochrane Central will be searched up to September 2022. Discussion: To the best of our knowledge, this will be the first scoping review to provide a comprehensive overview of the topic. The results could add meaningful information for future research and, especially, for clinical practice, when implementing telerehabilitation in cystic fibrosis treatment. Furthermore, we expect that our work may identify possible knowledge gaps on the topic. The results of this research will be published in a peer-reviewed journal and will be presented at relevant international scientific events, such as in congress or meetings. Full article

Movies beyond the scope of Hollywood and entertainment have shaped notions of race in American culture since the early decades of cinema. A range of nontheatrical sponsors and creators in the US made films to serve practical functions in society—to inform, to organize, to persuade, to promote, etc. The US federal government was a major sponsor of many of these films, which provided American and foreign audiences depictions of race that differed considerably from popular commercial images. For example, Men of the Forest, a film made in 1952 by the United States Information Service focuses on the Hunters, a Black family who owns land and a forestry business in rural Georgia. A documentary of sorts, the film highlights Black life, work, and land ownership in the South in ways not seen in popular feature films of the day. Yet, in the film and others like it, histories of institutional racism are woven into cinematic form and content in ways that are distinct from the entertainment industry. The creators of Men of the Forest omit details of segregation in the South to emphasize the Hunter family as examples of American democracy, a choice suited to the film’s Cold War purpose: to counter the anti-American message of Soviet propaganda for foreign audiences. On one hand, by producing and distributing the film, the federal government acknowledged Black farmers and landowners in the Jim Crow South. On the other hand, it avoided the structural inequality surrounding the Hunters to frame their reality as an example of American democratic progress for international circulation. Today, government films like Men of the Forest prompt contemporary reflection on the institutional histories they represent and their evolution into the present. The film and many others are available online due to the digitization of collections from the National Archives, Library of Congress, and elsewhere. With this increase in access, contemporary scholars have the ability to investigate how the federal government and its various internal entities mediated racial ideologies with moving image technologies. As an example of such research, this essay examines Men of the Forest by focusing on the past and present contradictions that arise from its depiction of a Black family with land and an agricultural business in rural Georgia. Two recent events shed light on the histories reflected in the film and their contemporary significance. In 2018, Descendants of Men of the Forest, The Legacy Continues—a documentary created by family members of the film’s original participants—contextualized the original production as evidence of the Hunter family’s legacy in the community of Guyton, Georgia. Underlying this local effort, Men of the Forest serves as an important historical event and record of the family and the community. On a broader scale, in March 2021, Congress passed a large relief package for disadvantaged minority farmers, intended to help alleviate decades of systemic racism in government agricultural programs. Lawsuits from white farmers and conservative organizations followed quickly, challenging the provision of government aid based on race. In this federal context, Men of the Forest exposes an institutional image of individual success that downplays the structural racism facing people of color, especially those with agricultural livelihoods. Even as politics and legislation evolve, this vision of democracy once exported by the federal government has widespread currency and accumulating effects. The connections between Men of the Forest and these recent events reveal the racial politics at play in government films and the ways in which they take shape in the real world beyond the screen. Full article

AbobotulinumtoxinA (aboBoNT-A) has been used for various cosmetic purposes, including minimization of moderate to severe lines, or other cosmetic indications, in the face and neck. We carried out a systematic review to identify all relevant evidence on the treatment approaches and outcomes of aboBoNT-A as a cosmetic treatment of the middle and lower areas of the face, and the neck. Embase, MEDLINE, Cochrane Library, congress proceedings and review bibliographies were searched for relevant studies. Identified articles were screened against pre-specified eligibility criteria. Of 560 unique articles identified, 10 were included for data extraction (three observational studies, 1 randomized controlled trial [with two articles] and five non-randomized trials). The articles provided data on gummy/asymmetric smile (2), marionette lines (5), masseter muscle volume (2), nasal wrinkles (2), perioral wrinkles (3) and the platysma muscle (4). All articles reporting on efficacy of aboBoNT-A demonstrated positive results, including reduction of wrinkles (5), reduction of masseter muscle (2) and degree of gummy smile (1) compared with before treatment. No serious adverse events were reported and patient satisfaction was high. In conclusion, positive findings support further research of aboBoNT-A for the middle and lower areas of the face, and in the neck, which are largely unapproved indications. Full article

Background and Objectives: Data emerging from the Women’s Health Initiative (WHI) study point toward an association between menopausal hormone therapy (MHT) and cardiovascular (CV) risk. However, post hoc subgroup analyses stratifying participants according to their age and time since menopause, have opened the way to a better understanding of the relationship between estrogen and CV risk. The aim of this review was to revise the current literature and evaluate the CV risk or benefit following administration of MHT considering several factors such as MHT timing, dose, route of administration, and formulation. Materials and Methods: An electronic databases search of MEDLINE (PubMed), Cochrane Central Register of Controlled Trials, Web of Science, SCOPUS, congress abstracts, and Grey literature (Google Scholar; British Library) was performed, with the date range from each database’s inception until June 2019. All the studies evaluating MHT and cardiovascular risk, including thromboembolism or stroke, were selected. Results: Timing of MHT initiation was shown to be a critical factor in CV risk assessment. In concordance with the “timing hypothesis”, healthy symptomatic women who initiated MHT when aged younger than 60 years, or who were within 10 years of menopause onset, have demonstrated a reduction in both coronary heart disease (CHD) risk and all-cause mortality. In particular, MHT therapy was associated with improvement of subclinical signs of atherosclerosis. Venous thromboembolism (VTE) risk is reduced when low doses of oral estrogen are used. Moreover, transdermal hormonal application significantly reduces CV risk compared with oral administration. MHT impact on the CV system is influenced by either factors inherent to the specific regimen, or factors inherent to the specific patient. Hence, individualization of care is necessary. Conclusion: CV risk calculation should be considered by clinicians in order to exclude patients with high CV risk, in whom MHT is contraindicated. Assessing risks and benefits in a patient-centered approach according to individual’s features, health status, and personal preferences is important in order to realize a safe and effective treatment. Full article

This article explores the challenges posed by an archival interest in the broad palimpsest of daily life left on social networks that are controlled by private corporations. It addresses whether social networks should be archived for the benefit of future generations and proposes a policy thought experiment to help grapple with these questions, namely, the proposal for the formation of the public interest-oriented Networked Memory Project by the Library of Congress for the archiving of social networks. My discussion of the challenges posed by this thought experiment will focus on the U.S. legal framework within which the Library of Congress operates and take Facebook. To the extent that social networks have user-generated contents that range from the highly “private” to “public” as opposed to other networked platforms that contain materials that are considered “public”, the bar for the historical archival of social networks is much higher. Almost every archival effort must contend with the legal hurdle of copyright, but the archiving of social networks must also address how to handle the potentially sensitive nature of materials that are considered “private” from the perspective of the social and legal constructions of privacy. My theoretical exercise of proposing the formation of the Networked Memory Project by the Library of Congress responds to the need to consider the benefits of a public interest-oriented archive of social networks that can counter the drawbacks of the incidental corporate archiving taking place on social networks. Full article