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Keywords = Raman flow cytometry (RFC)

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16 pages, 4900 KiB  
Review
Raman Flow Cytometry and Its Biomedical Applications
by Jiayang Xu, Hongyi Chen, Ce Wang, Yuting Ma and Yizhi Song
Biosensors 2024, 14(4), 171; https://doi.org/10.3390/bios14040171 - 31 Mar 2024
Cited by 2 | Viewed by 5068
Abstract
Raman flow cytometry (RFC) uniquely integrates the “label-free” capability of Raman spectroscopy with the “high-throughput” attribute of traditional flow cytometry (FCM), offering exceptional performance in cell characterization and sorting. Unlike conventional FCM, RFC stands out for its elimination of the dependency on fluorescent [...] Read more.
Raman flow cytometry (RFC) uniquely integrates the “label-free” capability of Raman spectroscopy with the “high-throughput” attribute of traditional flow cytometry (FCM), offering exceptional performance in cell characterization and sorting. Unlike conventional FCM, RFC stands out for its elimination of the dependency on fluorescent labels, thereby reducing interference with the natural state of cells. Furthermore, it significantly enhances the detection information, providing a more comprehensive chemical fingerprint of cells. This review thoroughly discusses the fundamental principles and technological advantages of RFC and elaborates on its various applications in the biomedical field, from identifying and characterizing cancer cells for in vivo cancer detection and surveillance to sorting stem cells, paving the way for cell therapy, and identifying metabolic products of microbial cells, enabling the differentiation of microbial subgroups. Moreover, we delve into the current challenges and future directions regarding the improvement in sensitivity and throughput. This holds significant implications for the field of cell analysis, especially for the advancement of metabolomics. Full article
(This article belongs to the Special Issue Recent Advances and Perspectives of Spectroscopy-Based Biosensors)
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