Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (2)

Search Parameters:
Keywords = RVA strain classification

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
26 pages, 5920 KiB  
Article
Complete Genome Classification System of Rotavirus alphagastroenteritidis: An Updated Analysis
by Ricardo Gabriel Díaz Alarcón, Karina Salvatierra, Emiliano Gómez Quintero, Domingo Javier Liotta, Viviana Parreño and Samuel Orlando Miño
Viruses 2025, 17(2), 211; https://doi.org/10.3390/v17020211 - 31 Jan 2025
Viewed by 1212
Abstract
Rotavirus alphagastroenteritidis is the major causative agent of acute gastroenteritis in both children under the age of 5 and young mammals and birds globally. RVAs are non-enveloped viruses with a genome comprising 11 double-stranded RNA segments. In 2008, the Rotavirus Classification Working Group [...] Read more.
Rotavirus alphagastroenteritidis is the major causative agent of acute gastroenteritis in both children under the age of 5 and young mammals and birds globally. RVAs are non-enveloped viruses with a genome comprising 11 double-stranded RNA segments. In 2008, the Rotavirus Classification Working Group pioneered a comprehensive and complete RVA genome classification system, establishing a specific threshold, which measures the genetic distances between homologous genes. The aim of this study was to perform an updated systematic analysis of the genetic variability across all RVA genes. Our investigation involved assessing the established cutoff values for each RVA genome segment and determining the need for any updates. To achieve this objective, multiple sequence alignments were constructed for all 11 genes and one for each genotype with discrepancies. Also, pairwise distances along with their cutoff values were evaluated. The analyses provided insights into the current relevance of cutoff values, which remain applicable for the majority of genotypes. In conclusion, this study fortifies the current classification system by highlighting its robustness and accurate genotyping of Rotavirus alphagastroenteritidis. Full article
(This article belongs to the Special Issue Virus Bioinformatics 2024)
Show Figures

Figure 1

10 pages, 878 KiB  
Article
Whole Genome Sequence Analysis of a Prototype Strain of the Novel Putative Rotavirus Species L
by Reimar Johne, Katja Schilling-Loeffler, Rainer G. Ulrich and Simon H. Tausch
Viruses 2022, 14(3), 462; https://doi.org/10.3390/v14030462 - 24 Feb 2022
Cited by 33 | Viewed by 2965
Abstract
Rotaviruses infect humans and animals and are a main cause of diarrhea. They are non-enveloped viruses with a genome of 11 double-stranded RNA segments. Based on genome analysis and amino acid sequence identities of the capsid protein VP6, the rotavirus species A to [...] Read more.
Rotaviruses infect humans and animals and are a main cause of diarrhea. They are non-enveloped viruses with a genome of 11 double-stranded RNA segments. Based on genome analysis and amino acid sequence identities of the capsid protein VP6, the rotavirus species A to J (RVA-RVJ) have been defined so far. In addition, rotaviruses putatively assigned to the novel rotavirus species K (RVK) and L (RVL) have been recently identified in common shrews (Sorex araneus), based on partial genome sequences. Here, the complete genome sequence of strain KS14/0241, a prototype strain of RVL, is presented. The deduced amino acid sequence for VP6 of this strain shows only up to 47% identity to that of RVA to RVJ reference strains. Phylogenetic analyses indicate a clustering separated from the established rotavirus species for all 11 genome segments of RVL, with the closest relationship to RVH and RVJ within the phylogenetic RVB-like clade. The non-coding genome segment termini of RVL showed conserved sequences at the 5′-end (positive-sense RNA strand), which are common to all rotaviruses, and those conserved among the RVB-like clade at the 3′-end. The results are consistent with a classification of the virus into a novel rotavirus species L. Full article
(This article belongs to the Section Animal Viruses)
Show Figures

Figure 1

Back to TopTop