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Keywords = Pt-Black/PEDOT-GO

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15 pages, 4096 KB  
Article
Flexible Neural Probes with Electrochemical Modified Microelectrodes for Artifact-Free Optogenetic Applications
by Bangbang Guo, Ye Fan, Minghao Wang, Yuhua Cheng, Bowen Ji, Ying Chen and Gaofeng Wang
Int. J. Mol. Sci. 2021, 22(21), 11528; https://doi.org/10.3390/ijms222111528 - 26 Oct 2021
Cited by 13 | Viewed by 3381
Abstract
With the rapid increase in the use of optogenetics to investigate nervous systems, there is high demand for neural interfaces that can simultaneously perform optical stimulation and electrophysiological recording. However, high-magnitude stimulation artifacts have prevented experiments from being conducted at a desirably high [...] Read more.
With the rapid increase in the use of optogenetics to investigate nervous systems, there is high demand for neural interfaces that can simultaneously perform optical stimulation and electrophysiological recording. However, high-magnitude stimulation artifacts have prevented experiments from being conducted at a desirably high temporal resolution. Here, a flexible polyimide-based neural probe with polyethylene glycol (PEG) packaged optical fiber and Pt-Black/PEDOT-GO (graphene oxide doped poly(3,4-ethylene-dioxythiophene)) modified microelectrodes was developed to reduce the stimulation artifacts that are induced by photoelectrochemical (PEC) and photovoltaic (PV) effects. The advantages of this design include quick and accurate implantation and high-resolution recording capacities. Firstly, electrochemical performance of the modified microelectrodes is significantly improved due to the large specific surface area of the GO layer. Secondly, good mechanical and electrochemical stability of the modified microelectrodes is obtained by using Pt-Black as bonding layer. Lastly, bench noise recordings revealed that PEC noise amplitude of the modified neural probes could be reduced to less than 50 µV and no PV noise was detected when compared to silicon-based neural probes. The results indicate that this device is a promising optogenetic tool for studying local neural circuits. Full article
(This article belongs to the Special Issue Electroconductive Materials in Tissue Engineering)
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