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Bahía de Los Ángeles (BLA) is located on the peninsular coast of the Gulf of California, near to the midriff islands. It is a greatly diverse ecosystem and a marine protected area due to its importance for whale sharks, turtles, and reef fishes. The bay also supports commercial fisheries that require ecological information for the integrated management of resources. Zooplankton studies are required as is an essential link in the trophic webs. There are few zooplankton studies in BLA focused mainly on the major taxa and species of copepods and cladocerans. Only one study addressed the seasonal variation in zooplankton but with gaps in the sampling. Here, we report the monthly changes in the zooplankton abundance and the composition of the major groups and cladoceran species. Eighty-one samples were collected between September 2017 and January 2019. The holoplankton taxa identified numbered 17, which accounts for 93% of the mean abundance (range 71–100%), with copepods and cladocerans being dominant. The meroplankton consisted of 15 taxa with a greater presence during the warm months (summer–autumn), dominated by the larval stages of bivalves, gastropods, and barnacles. In contrast, many copepod nauplii were found in January associated with low temperatures. Only cladacerans were identified to the species level. They showed strong seasonal fluctuations, reaching a third of the total zooplankton from spring to autumn, with Penilia avirostris being the most abundant species. These results are compared with other temperate and tropical coastal locations of the eastern Pacific. Full article