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Keywords = Praescutata viperina toxin

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11 pages, 682 KiB  
Article
Comparison of Sea Snake (Hydrophiidae) Neurotoxin to Cobra (Naja) Neurotoxin
by Yumiko Komori, Masaya Nagamizu, Kei-ichi Uchiya, Toshiaki Nikai and Anthony T. Tu
Toxins 2009, 1(2), 151-161; https://doi.org/10.3390/toxins1020151 - 3 Dec 2009
Cited by 4 | Viewed by 11605
Abstract
Both sea snakes and cobras have venoms containing postsynaptic neurotoxins. Comparison of the primary structures indicates many similarities, especially the positions of the four disulfide bonds. However, detailed examination reveals differences in several amino acid residues. Amino acid sequences of sea snake neurotoxins [...] Read more.
Both sea snakes and cobras have venoms containing postsynaptic neurotoxins. Comparison of the primary structures indicates many similarities, especially the positions of the four disulfide bonds. However, detailed examination reveals differences in several amino acid residues. Amino acid sequences of sea snake neurotoxins were determined, and then compared to cobra neurotoxins by computer modeling. This allowed for easy comparison of the similarities and differences between the two types of postsynaptic neurotoxins. Comparison of computer models for the toxins of sea snakes and cobra will reveal the three dimensional difference of the toxins much clearer than the amino acid sequence alone. Full article
(This article belongs to the Special Issue Neurotoxins of Biological Origin)
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