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Keywords = Plenckia populnea

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11 pages, 2517 KiB  
Article
Cytotoxic Triterpenes from Salacia crassifolia and Metabolite Profiling of Celastraceae Species
by Laila S. Espindola, Renata G. Dusi, Daniel P. Demarque, Raimundo Braz-Filho, Pengcheng Yan, Heidi R. Bokesch, Kirk R. Gustafson and John A. Beutler
Molecules 2018, 23(6), 1494; https://doi.org/10.3390/molecules23061494 - 20 Jun 2018
Cited by 21 | Viewed by 5858
Abstract
The new pentacyclic triterpene 11β-hydroxypristimerin (1), along with the known metabolites pristimerin (2), 6-oxopristimerol (3) and vitideasin (4), were isolated from a Salacia crassifolia root wood extract, following a bioassay-guided fractionation approach. Both [...] Read more.
The new pentacyclic triterpene 11β-hydroxypristimerin (1), along with the known metabolites pristimerin (2), 6-oxopristimerol (3) and vitideasin (4), were isolated from a Salacia crassifolia root wood extract, following a bioassay-guided fractionation approach. Both the extract and the purified triterpenes displayed pronounced cytotoxic activity against human cancer cell lines. The NCI-60 cell line screen revealed that compound 2 was the most active, with a mean GI50 of 0.17 μM, while compound 1 had a mean GI50 of 8.7 μM. A COMPARE analysis of the screening results showed that pristimerin is likely to be the main compound responsible for the cytotoxic activity of the extract (mean GI50 of 0.3 μg·mL−1). A targeted search for pristimerin and related derivatives using LC-MS/MS revealed the presence of pristimerin (2) and 6-oxopristimerol (3) in all Celastraceae species examined and in all plant parts tested, while vitideasin (4) was only detected in the genus Salacia. Full article
(This article belongs to the Special Issue Antitumoral Properties of Natural Products)
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