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16 pages, 2325 KiB

Open AccessArticle

Identifying Key Environmental Factors for Paulownia coreana Habitats: Implementing National On-Site Survey and Machine Learning Algorithms

by Yeeun Shin, Suyeon Kim, Se-Rin Park, Taewoo Yi, Chulgoo Kim, Sang-Woo Lee and Kyungjin An

Land 2022, 11(4), 578; https://doi.org/10.3390/land11040578 - 14 Apr 2022

Cited by 4 | Viewed by 2416

Abstract

Monitoring and preserving natural habitats has become an essential activity in many countries today. As a native tree species in Korea, Paulownia coreana has periodically been surveyed in national ecological surveys and was identified as an important target for conservation as well as habitat monitoring and management. This study explores habitat suitability models (HSMs) for Paulownia coreana in conjunction with national ecological survey data and various environmental factors. Together with environmental variables, the national ecological survey data were run through machine learning algorithms such as Artificial Neural Network and Decision Tree & Rules, which were used to identify the impact of individual variables and create HSMs for Paulownia coreana, respectively. Unlike other studies, which used remote sensing data to create HSMs, this study employed periodical on-site survey data for enhanced validity. Moreover, localized environmental resources such as topography, soil, and rainfall were taken into account to project habitat suitability. Among the environment variables used, the study identified critical attributes that affect the habitat conditions of Paulownia coreana. Therefore, the habitat suitability modelling methods employed in this study could play key roles in planning, monitoring, and managing plants species in regional and national levels. Furthermore, it could shed light on existing challenges and future research needs. Full article

(This article belongs to the Special Issue Advances in Sustainable Forest Management)

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2 pages, 123 KiB

Open AccessCorrection

Response to Wiart, C. Lee et al., Inhibitory Effect and Mechanism of Antiproliferation of Isoatriplicolide Tiglate (PCAC) from Paulownia coreana. Molecules 2012, 17, 5945-5951: A Note Regarding Paulownia coreana. Molecules 2013, 18, 2587-2588.

by Myeong-Sok Lee

Molecules 2013, 18(3), 3041-3042; https://doi.org/10.3390/molecules18033041 - 7 Mar 2013

Viewed by 4577

Abstract

In a Comment recently published in Molecules [1], Prof. C. Wiart took issue with our identification of the plant species used in our work as Paulownia coreana. Although this name was assigned by H. Uyeki in 1925 [2], appears as such in handbooks of Korean flora [3], and examples of its use can be found in the recent literature [4–9], after reviewing the arguments and references presented in [1], we now recognize that this is no longer considered an accepted species name, and therefore we wish to revise our assignment to Pauwlonia tormentosa (Thunb.) Steud. We thank Prof. Wiart for bringing this fact to our attention and apologize to the readership of Molecules for any confusion caused by our previous classification of the species. [...] Full article

2 pages, 127 KiB

Open AccessComment

Lee et al., Inhibitory Effect and Mechanism of Antiproliferation of Isoatriplicolide Tiglate (PCAC) from Paulownia Coreana. Molecules 2012, 17, 5945-5951: A Note Regarding Paulownia coreana.

by Christophe Wiart

Molecules 2013, 18(3), 2587-2588; https://doi.org/10.3390/molecules18032587 - 26 Feb 2013

Cited by 1 | Viewed by 4792

Abstract

I read with interest the article by Lee et al. entitled “Inhibitory Effect and Mechanism of Antiproliferation of Isoatriplicolide Tiglate (PCAC) from Paulownia Coreana” [1]. This article is quite interesting and the authors should be complimented for the significant amount of work they have done. The purpose of this letter is to call attention to the need for some clarification on the name of the plant described in this article. Lee et al. state: “Paulownia coreana has traditionally been used as the medicine and health food in the treatment of cancer and infectious diseases.” and elsewhere: “In fact, many cancer research studies have been conducted using traditional medicinal plants such as P. coreana.” [1]. Full article

(This article belongs to the Section Natural Products Chemistry)

7 pages, 599 KiB

Open AccessCommunication

Inhibitory Effect and Mechanism on Antiproliferation of Isoatriplicolide Tiglate (PCAC) from Paulownia Coreana

by Samil Jung, Hyung-In Moon, Jiyeon Ohk, Soonduck Lee, Chengping Li, Soo-Ki Kim and Myeong-Sok Lee

Molecules 2012, 17(5), 5945-5951; https://doi.org/10.3390/molecules17055945 - 18 May 2012

Cited by 12 | Viewed by 5156 | Correction

Abstract

Paulownia coreana has traditionally been used as the medicine and health food in the treatment of cancer and infectious diseases. In the present study, a new antiproliferation agent, isoatriplicolide tiglate (PCAC) was isolated from the chloroform soluble fraction of the leaves of Paulownia coreana. The antiproliferation activities of PCAC plant extract was examined in breast and cervical cancer cell lines in a time-and dose-dependent manners. Our in vitro experiments showed that PCAC suppresses the cell growth and proliferation of cancer cells at a relatively low concentration ( < 10 µg/mL) and induces apoptosis at a high concentration ( > 50 µg/mL). Western blot analysis showed that concentration higher than 50 µg/mL induces a time-dependent increase in the percentage of apoptotic cells. In this case, PCAC uses both extrinsic and intrinsic pathways for the apoptosis. PCAC treatment decreased the expression of pro-caspase 8, 9, and 3, the main regulators of apoptotic cell death, in MDA-MB-231 cells, accompanied by the activation of caspase 8, 9, and 3. More importantly, PCAC inhibited the in vitro proliferation of six other human breast and cervical cancer cell lines. In conclusion, our data strongly suggest that PCAC acts as an antiproliferation agents particularly against breast and cervical cancers by inducing cell cycle arrest in the S/G2 phase and caspase dependent apoptosis at relatively low ( < 10 μg/mL) and high ( > 50 µg/mL) concentrations, respectively. Full article

(This article belongs to the Section Natural Products Chemistry)

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