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15 pages, 2290 KiB  
Article
Identification of Candidate Genes and Pathways Linked to the Temperament Trait in Sheep
by Estefanía Romaniuk, Brenda Vera, Pablo Peraza, Gabriel Ciappesoni, Juan Pablo Damián and Elize Van Lier
Genes 2024, 15(2), 229; https://doi.org/10.3390/genes15020229 - 11 Feb 2024
Cited by 5 | Viewed by 2198
Abstract
Temperament can be defined as the emotional variability among animals of the same species in response to the same stimulus, grouping animals by their reactivity as nervous, intermediate, or calm. Our goal was to identify genomic regions with the temperament phenotype measured by [...] Read more.
Temperament can be defined as the emotional variability among animals of the same species in response to the same stimulus, grouping animals by their reactivity as nervous, intermediate, or calm. Our goal was to identify genomic regions with the temperament phenotype measured by the Isolation Box Test (IBT) by single-step genome-wide association studies (ssGWAS). The database consisted of 4317 animals with temperament records, and 1697 genotyped animals with 38,268 effective Single Nucleotide Polymorphism (SNP) after quality control. We identified three genomic regions that explained the greatest percentage of the genetic variance, resulting in 25 SNP associated with candidate genes on chromosomes 6, 10, and 21. A total of nine candidate genes are reported for the temperament trait, which is: PYGM, SYVN1, CAPN1, FADS1, SYT7, GRID2, GPRIN3, EEF1A1 and FRY, linked to the energetic activity of the organism, synaptic transmission, meat tenderness, and calcium associated activities. This is the first study to identify these genetic variants associated with temperament in sheep, which could be used as molecular markers in future behavioral research. Full article
(This article belongs to the Section Animal Genetics and Genomics)
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